Controlling physicochemical properties of graphene oxide for efficient cellular delivery

Heo, Jiwoong; Tanum, Junjira; Park, Sohyeon; Choi, Daheui; Jeong, Hyejoong; Han, Uiyoung; Hong, Jinkee

doi:10.1016/j.jiec.2020.04.030

Cited by 11 publications

(12 citation statements)

References 30 publications

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“…A needle-like GO nanocarrier obtained via conformational change of GO sheets using salt ions in the cell growth medium, was characterized with high surface area and satisfactory number of functional groups for DOX accumulation on the GO sheets. GO needles showed convenable biocompatibility at concentrations <100 μg/mL and after loading with DOX they showed ameliorated anticancer effectiveness compared to free DOX caused by improved cellular endocytosis of a 1D needle structure [ 180 ]. GO co-loaded with both DOX and the apoptotic agent antimiR-21 released rapidly both loaded compounds in cancer cells, resulting in effective destroying of cancer cells, whereby a low DOX dose was sufficient for the inhibition of MDA-MB-231 cells and antimiR-21 caused silencing of miR-21, upregulation of which is associated with numerous types of cancer [ 181 ].…”

Section: Graphene Oxidementioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

2021

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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Section: Graphene Oxidementioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

2021

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“…[139] However, a previous study showed that despite having a large length, some needle-like GBMs (length of 1.1 mm) can efficiently internalize into the cytoplasm of human dermal fibroblast cells. [140] By labeling GO with gold NMs and tracing them using surfaceenhanced Raman scattering spectroscopy, Huang et al documented that GO can enter Ca Ski (human cervix (small bowel metastasis)) cells mainly through clathrin-mediated, energydependent endocytosis and distribute inside the cells. [27] A small variation in lateral size could result in a big difference in the pathway through which GBMs enter cells.…”

Section: Cellular Uptakementioning

confidence: 99%

“…Functionalization of graphene NMs with hydrophilic functional groups such as hydroxyl and carboxyl groups can facilitate their dispersion in physiological media. [140,151] Zhang et al applied sulfonic acid and folic acid groups for stabilization of GO NMs under physiological conditions. [152] However, there are some challenges associated with the functionalization of graphene sheets to increase their dispersion in physiological media.…”

Section: Cellular Uptakementioning

confidence: 99%

“…For example, Heo et al reported that ions and electrolytes in model physiological media can interact with the edges of GO sheet, which are functionalized with carboxyl groups, and lead to sheet agglomeration and/or the roll-up of the sheets. [140] A previous study claimed that PEGylated GO exhibits excellent aqueous solubility. [146a] It is also possible that GBMs may not be captured by the lipid bilayer, and consequently, are not taken up.…”

Section: Cellular Uptakementioning

confidence: 99%

Section: Uptake and Biodistribution Of Gbmsmentioning

confidence: 99%

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Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

et al. 2021

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drug delivery, bioimaging probes, antibacterial agents, and tissue engineering. [2] The advantage of GBMs over other nanomaterials (NMs) in biomedical application is their high specific surface area which allows high density functionalization and drug loading on both sides of the planar structure. [3] The π-conjugated system offers high capacity for GBMs to interact with various organic compounds with aromatic structures through π-π stacking during fabrication of graphene composites or for immobilization of biomolecules such as nucleic acids, peptides, antibodies, or other therapeutic substances. [4] The same properties may also raise concerns regarding the potential risk that GBMs may cause to human health through binding of key signaling molecules for example. GBMs may interact with biomolecules, changing the structure of protein or DNA or induce oxidative damage, and so on. [5] Therefore, prior to the widespread use of GBMs, it is imperative to evaluate their potential risk to environmental and human health and to establish a proactive approach for the safe design of these materials.In a recent review article, Fadeel et al. comprehensively examined the literature on the effects of GBMs on human health and the environment and gave an overview of the state-of-the-art of safety assessment of GBMs, highlighting the importance of The increasing exploitation of graphene-based materials (GBMs) is driven by their unique properties and structures, which ignite the imagination of scientists and engineers. At the same time, the very properties that make them so useful for applications lead to growing concerns regarding their potential impacts on human health and the environment. Since GBMs are inert to reaction, various attempts of surface functionalization are made to make them reactive. Herein, surface functionalization of GBMs, including those intentionally designed for specific applications, as well as those unintentionally acquired (e.g., protein corona formation) from the environment and biota, are reviewed through the lenses of nanotoxicity and design of safe materials (safe-by-design). Uptake and toxicity of functionalized GBMs and the underlying mechanisms are discussed and linked with the surface functionalization. Computational tools that can predict the interaction of GBMs behavior with their toxicity are discussed. A concise framing of current knowledge and key features of GBMs to be controlled for safe and sustainable applications are provided for the community.

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Accessibility of grafted functional groups limits reactivity of covalent graphene derivatives

Pykal

Vondrák

Šrejber

et al. 2022

Applied Surface Science

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Controlling physicochemical properties of graphene oxide for efficient cellular delivery

Cited by 11 publications

References 30 publications

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

Accessibility of grafted functional groups limits reactivity of covalent graphene derivatives

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