Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy

Feng, Xiaohui; Zhang, Shaokun; Lou, Xia

doi:10.1016/j.colsurfb.2013.02.007

Cited by 86 publications

(47 citation statements)

References 28 publications

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“…Light triggering with the energy greater than the band gap (3.2 eV for anatase) generates the electrons from valance band to the conduction band, forming electronic vacancies in the valance band. The highly reactive electrons and holes can further react with water molecules to form various ROS, such as hydroxyl (OH•), superoxide anions (O 2 −• ), hydroperoxyl (HO 2 •) radicals, singlet oxygen ( 1 O 2 ) and hydrogen peroxide (H 2 O 2 ) . These as‐formed ROS can induce the cell death because of their highly reactive nature with the organic species intracellularly.…”

Section: Inorganic Micro/nanoparticle‐augmented Sonosensitizermentioning

confidence: 99%

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

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The fast development of photoactivation for cancer treatment provides an efficient photo-therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues. As a non-invasive therapeutic modality, sonodynamic therapy (SDT) can break the depth barrier of photoactivation because ultrasound has an intrinsically high tissue-penetration performance. Micro/nanoparticles can efficiently augment the SDT efficiency based on nanobiotechnology. The state-of-art of the representative achievements on micro/nanoparticle-enhanced SDT is summarized, and specific functions of micro/nanoparticles for SDT are discussed, from the different viewpoints of ultrasound medicine, material science and nanobiotechnology. Emphasis is put on the relationship of structure/composition-SDT performance of micro/nanoparticle-based sonosensitizers. Three types of micro/nanoparticle-augmented SDT are discussed, including organic and inorganic sonosensitizers and micro/nanoparticle-based but sonosensitizer-free strategies to enhance the SDT outcome. SDT-based synergistic cancer therapy augmented by micro/nanoparticles and their biosafety are also included. Some urgent critical issues and potential developments of micro/nanoparticle-augmented SDT for efficient cancer treatment are addressed. It is highly expected that micro/nanoparticle-augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment. At the same time, fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.

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Section: Inorganic Micro/nanoparticle‐augmented Sonosensitizermentioning

confidence: 99%

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

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“…Unlike TiO 2 nanoparticles, which tend to aggregate and lack the ability to accumulate specifically on cancer cells [18,19], TiO 2 nanofibers can disperse pretty well in aqueous solutions and consequently attach on the cell surface [20][21][22]. More importantly, TiO 2 nanofibers have been proven to possess good biocompatibility and are believed to be a candidate as a promising UV light photosensitizer for PDT [23,24].…”

Section: Introductionmentioning

confidence: 99%

Enhanced photodynamic therapy of mixed phase TiO2(B)/anatase nanofibers for killing of HeLa cells

et al. 2014

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Photodynamic therapy (PDT), which is a procedure that uses photosensitizing drug to apply therapy selectively to target sites, has been proven to be a safe treatment for cancers and conditions that may develop into cancers. Nano-sized TiO 2 has been regarded as potential photosensitizer for UV light driven PDT. In this study, four types of TiO 2 nanofibers were prepared from proton tri-titanate (H 2 T 3 O 7 ) nanofiber. The as-obtained nanofibers were demonstrated as efficient photosensitizers for PDT killing of HeLa cells. MTT assay and flow cytometry (FCM) were carried out to evaluate the biocompatibility, percentage of apoptotic cells, and cell viability. The non-cytotoxicity of the as-prepared TiO 2 nanofibers in the absence of UV irradiation has also been demonstrated. Under UV light irradiation, the TiO 2 nanofibers, particularly the mixed phase nanofibers, displayed much higher cell-killing efficiency than Pirarubicin (THP), which is a common drug to induce the apoptosis of HeLa cells. We ascribe the high cellkilling efficiency of the mixed phase nanofibers to the bandgap edge match and stable interface between TiO 2 (B) and anatase phases in a single nanofiber, which can inhibit the recombination of the photogenerated electrons and holes. This promotes the charge separation and transfer processes and can produce more reactive oxygen species (ROS) that are responsible for the killing of HeLa cells.

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“…Synthesis and characterization of carbon-freeM agnØli nanoparticles Commercially available P25 titania was used as titaniump recursor.T his powder contains am ixture of 80 wt %a natasea nd 20 wt %r utile TiO 2 with approximately 35 nm particle size, as shownb yT EM (Figure 2a). Silica-coatedT iO 2 nanoparticles were prepared by the Stçber method [22] from tetraethyl orthosilicate as silica precursor,which was added to an alcoholic suspensiono fP 25 under basic conditions. TEM (Figure 2b)c onfirmed that TiO 2 -SiO 2 core-shell nanoparticles were obtained, with an 8nm-thicks ilicas hell showing lower contrastt han the crystalline TiO 2 core.…”

Section: Resultsmentioning

confidence: 99%

Different Reactivity of Rutile and Anatase TiO₂ Nanoparticles: Synthesis and Surface States of Nanoparticles of Mixed‐Valence Magnéli Oxides

Baktash

Capitolis

Tinat

et al. 2019

Chemistry A European J

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MagnØli phasesT i n O 2nÀ1 (3 < n 10) are mixed Ti 4 + /Ti 3 + oxides with high electrical conductivity.W hen used for water remediation or electrochemical energys toragea nd conversion, they are nanostructured and exposed to various environments. Therefore, understandingt heir surfacer eactivity is of prime importance.S uch studies have been hindered by carbon contamination from syntheses. Herein, this synthetic and characterization challengei sa ddressed throughan ew approacht o5 0nmc arbon-free Ti 4 O 7 and Ti 6 O 11 nanoparticles. It takes advantage of the differentr eac-tivitieso fr utile and anatase TiO 2 nanoparticles towards H 2 , to use the former as precursor of Ti n O 2nÀ1 and the latter as a diluting agent. This approachi sc ombined with silica templatingt or estrain particle growth. The surface reactivity of the MagnØli nanoparticles under different atmospheresw as then evaluated quantitatively by synchrotron-radiationbased X-ray photoelectron spectroscopy,w hichr evealed oxidized surfaces with lower conductivity than the core. This findings heds an ew light on the charget ransfer occurring in these materials.Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy

Cited by 86 publications

References 28 publications

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Enhanced photodynamic therapy of mixed phase TiO2(B)/anatase nanofibers for killing of HeLa cells

Different Reactivity of Rutile and Anatase TiO₂ Nanoparticles: Synthesis and Surface States of Nanoparticles of Mixed‐Valence Magnéli Oxides

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Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy

Cited by 86 publications

References 28 publications

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Enhanced photodynamic therapy of mixed phase TiO2(B)/anatase nanofibers for killing of HeLa cells

Different Reactivity of Rutile and Anatase TiO2 Nanoparticles: Synthesis and Surface States of Nanoparticles of Mixed‐Valence Magnéli Oxides

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Different Reactivity of Rutile and Anatase TiO₂ Nanoparticles: Synthesis and Surface States of Nanoparticles of Mixed‐Valence Magnéli Oxides