Controlling the chromatin organization of vitamin D target genes by multiple vitamin D receptor binding sites

Carlberg, Carsten; Dunlop, Thomas W.; Saramäki, Anna; Sinkkonen, Lasse; Matilainen, Merja; Vaïsänen, Sami

doi:10.1016/j.jsbmb.2006.12.044

Cited by 28 publications

(16 citation statements)

References 56 publications

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“…Genes that were down-regulated by 1,25(OH) 2 D 3 in POBs included those involved in cell cycle; those uniquely down-regulated in OBs were related to cell adhesion (BP, GO:0007155), including cadherin 1 (Cdh1), Col2a1, fibulin 5 (Fbln5), integrin binding sialoprotein (Ibsp), and osteomodulin (Omd). Although some regulated genes were novel, others are well recognized targets of vitamin D hormone action both in vitro and in vivo (33)(34)(35).…”

Section: Smoc2mentioning

confidence: 99%

Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 during Osteoblast-lineage Cell Differentiation

Meyer

Benkusky

Lee

et al. 2014

Journal of Biological Chemistry

102

120

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Background:The biological activities of 1,25(OH) 2 D 3 in osteoblasts are dependent upon their differentiation state. Results: Genome-wide analyses reveal transcriptomic responses to 1,25(OH) 2 D 3 , and VDR, RUNX2, and C/EBP␤ cistromes are modified during differentiation. Conclusion: Differentiation-induced changes in expression and transcription factor genome occupancy underlie the response to 1,25(OH) 2 D 3 . Significance: Transcription factor occupancy at genome sites is dynamic and significantly influenced by the state of cellular differentiation.

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Section: Smoc2mentioning

confidence: 99%

Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 during Osteoblast-lineage Cell Differentiation

Meyer

Benkusky

Lee

et al. 2014

Journal of Biological Chemistry

102

120

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“…A variety of posttranslational modifications of nuclear proteins, such as methylation, phosphorylation, ubiquitination, sumoylation, ADP ribosylation, and glycosylation, also regulate nuclear receptor signaling [16e18]. Dynamic modification is required for the coordinated interaction of VDRecofactor complexes and for efficient regulation of transcription [19].…”

Section: The Vitamin D Receptor Is a Dual-functional Receptor For Vitmentioning

confidence: 99%

The Bile Acid Derivatives Lithocholic Acid Acetate and Lithocholic Acid Propionate are Functionally Selective Vitamin D Receptor Ligands

Makishima

Yamada

2011

Vitamin D

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“…The expression of IGFBPs has been shown to be up-regulated by 1α,25(OH) 2 D and its analogs in different cancer cells including prostate [Boyle et al, 2001;Stewart et al, 2005], colon [Oh et al, 2001;Palmer et al, 2003], and breast [Swami et al, 2003]. Recently, a functional VDRE has been identified in the promoter region of IGFBPs [Peng et al, 2004;Matilainen et al, 2005;Carlberg et al, 2007], suggesting that IGFBPs may be the primary target genes of 1α,25(OH) 2 D and its analogs. Lee et al [2006a;2008] also reported that Gemini vitamin D analogs induce the expression of IGFBP-3 in estrogen receptor (ER)-positive and -negative animal models, as well as MCF10A series of breast epithelial cells.…”

Section: Cross-talk Of Vitamin D Signaling With Other Pathwaysmentioning

confidence: 99%

Vitamin D and breast cancer: Molecular communications

Lee

2011

J Korean Soc Appl Biol Chem

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Epidemiological studies have demonstrated that vitamin D status is inversely associated with breast cancer incidence, mortality, and recurrences, suggesting vitamin D as a potent agent to reduce the risk of breast cancer. The hormonally active metabolite of vitamin D, 1α,25-dihydroxyvitamin D (1α,25(OH) 2 D, calcitriol), and its analogs have exerted inhibitory activity of cellular proliferation through arresting cell cycle and inducing apoptosis, and suppressive effects on the invasion, angiogenesis, and metastasis of breast cancer. In the studies of molecular basis of vitamin D activities, many upstream signaling pathways cross-talking with vitamin D signaling have been investigated. 1α,25(OH) 2 D and its analogs regulates different signaling pathways mediated by transforming growth factor-β superfamily, epidermal growth factor receptors family, estrogen signaling-related molecules, insulin-like growth factor-binding proteins, and protein kinase C. The multipotent activities of vitamin D in signaling modulation may be efficient and effective in suppressing highly heterogeneous breast cancer.

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Controlling the chromatin organization of vitamin D target genes by multiple vitamin D receptor binding sites

Cited by 28 publications

References 56 publications

Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 during Osteoblast-lineage Cell Differentiation

Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 during Osteoblast-lineage Cell Differentiation

The Bile Acid Derivatives Lithocholic Acid Acetate and Lithocholic Acid Propionate are Functionally Selective Vitamin D Receptor Ligands

Vitamin D and breast cancer: Molecular communications

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