Controlling the Interaction of Nanoparticles with Cell Membranes by the Polymeric Tether

Abstract

The well control over the cell−nanoparticle interaction can be of great importance and necessity for different biomedical applications. In this work, we propose a new and simple way (i.e., polymeric tether) to tuning the interaction between nanoparticles and cell membranes by dissipative particle dynamics simulations. It is found that the linked nanoparticles (via polymeric tether) can show some cooperation during the cellular uptake and thereby have a higher wrapping degree than the single nanoparticle. The effect of the property of the polymer on the wrapping is also investigated, and it is found that the length, rigidity, and hydrophobicity of the polymer play an important role. More interestingly, the uptake of linked nanoparticles could be adjusted to the firm adhesion via two rigid polymeric tethers. The present study may provide some useful guidelines for novel design of functional nanomaterials in the experiments.

Effect of Cell Labeling on the Function of Human Pluripotent Stem Cell-Derived Cardiomyocytes

“…The transportation of labeling agents into the cells could change the biological responses of cells, such as metabolism, proliferation, and migration ( 4 - 6 ). Labeling agent-rich regions cause changes in the physical properties of the cell surface and thereby determine cellular characteristics, i.e., the cell surface, repulsion between cells, subsequent migration, and the uptake of ion ( 7 - 9 ). Ideal labeling agents should have high labeling efficiency and not have harmful effects on cellular function.…”

Molecular Simulation Studies on the Interactions of Bilirubin at Different States with a Lipid Bilayer

“…As shown in Figure a, BR consists of two nearly identical dipyrrinone subunits connected by a methylene group that allows flexible rotation, and thus, it has a lot of conformations under different situations. , In this work, for the sake of simplicity, four typical conformations of BR were considered (Figure b), where the Z , Z BR with stable intramolecular hydrogen bonds was the dominant conformation at the physiological environment, and the E,E BR without intermolecular hydrogen bonds was a typical conformation after phototherapy . The Z,Z_ion and E,E_ion indicated their ionized states (two carboxylic acids at C3, C18 completely ionized), respectively. − Moreover, to construct the lipid bilayer, 128 DOPC lipid molecules were fully hydrated in water without adding BR. − …”

Mechanism studies on the cellular internalization of nanoparticles using computer simulations: A review

“…If too long and rigid polymer molecular chain has been utilized, it will increase the distance between the nanoparticles and reduce the synergistic effect of the nanoparticles. 65…”