Controlling the Nucleation and Growth of Au on <i>a</i>-Se Nanospheres to Enhance Their Cellular Uptake and Cytotoxicity

Cheng, Haoyan; Wang, Chenxiao; Lyu, Zhiheng; Zhu, Zhihong; Xia, Younan

doi:10.1021/jacs.2c11053

Cited by 14 publications

(12 citation statements)

References 37 publications

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“…Chem. Soc.202314512161226 Catalytic System Based on Sub-2 nm Pt Particles and Its Extraordinary Activity and Durability for Oxygen ReductionChengH.CaoZ.ChenZ.ZhaoM.XieM.LyuZ.ZhuZ.ChiM.XiaY. Cheng, H. Cao, Z. Chen, Z. Zhao, M. Xie, M. Lyu, Z. Zhu, Z. Chi, M. Xia, Y.…”

Section: Key Referencesmentioning

confidence: 99%

“…It is mediated and controlled by the interactions between the receptors on the cell membrane and the ligands on the surface of a nanoparticle. The enriched diversity in terms of surface configuration for the Se–Au hybrid nanoparticles shown in Figure offers an opportunity to optimize the spatial distribution of ligands for enhanced cellular uptake and cytotoxicity . Specifically, the Au patches on the surface of a -Se nanoparticles can serve as a platform for the facile and reliable attachment of a targeting ligand such as folic acid-terminated thiol poly(ethylene glycol).…”

Section: Applicationsmentioning

confidence: 99%

“…In addition to those based on metals, we have also explored nonmetallic substrates for galvanic replacement synthesis. In one example, we demonstrated the use of amorphous Se ( a -Se) nanospheres as a substrate for the facile synthesis of Se–Au hybrid nanoparticles with a variety of morphologies ranging from Janus to core–shell structures . The key is to control the number of heterogeneous nucleation sites on the surface of an a -Se nanosphere by adjusting the kinetics associated with the galvanic replacement reaction.…”

Section: Nonmetallic Substratesmentioning

confidence: 99%

“… 2023 145 1216 1226 . 1 This work demonstrated the synthesis of Au nanoparticles from the surface of amorphous Se nanospheres through a galvanic replacement reaction, where the nucleation and growth pattern of Au could be manipulated by controlling the reaction kinetics . Catalytic System Based on Sub-2 nm Pt Particles and Its Extraordinary Activity and Durability for Oxygen Reduction Cheng H. Cao Z.…”

Section: Key Referencesmentioning

confidence: 99%

“…In one example, we demonstrated the use of amorphous Se ( a -Se) nanospheres as a substrate for the facile synthesis of Se–Au hybrid nanoparticles with a variety of morphologies ranging from Janus to core–shell structures. 1 The key is to control the number of heterogeneous nucleation sites on the surface of an a -Se nanosphere by adjusting the kinetics associated with the galvanic replacement reaction. When aqueous HAuCl 4 is added dropwise into an aqueous suspension of a -Se nanospheres and CTAB, Se atoms will be oxidized to Se IV and the released electrons will be captured by Au III to generate Au atoms via a reduction reaction ( Figure 5 A).…”

Section: Nonmetallic Substratesmentioning

confidence: 99%

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Galvanic Replacement Synthesis of Metal Nanostructures: Bridging the Gap between Chemical and Electrochemical Approaches

et al. 2023

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Conspectus Galvanic replacement synthesis involves oxidation and dissolution of atoms from a substrate while the salt precursor to another material with a higher reduction potential is reduced and deposited on the substrate. The driving force or spontaneity of such a synthesis comes from the difference in reduction potential between the redox pairs involved. Both bulk and micro/nanostructured materials have been explored as substrates for galvanic replacement synthesis. The use of micro/nanostructured materials can significantly increase the surface area, offering immediate advantages over the conventional electrosynthesis. The micro/nanostructured materials can also be intimately mixed with the salt precursor in a solution phase, resembling the setting of a typical chemical synthesis. The reduced material tends to be directly deposited on the surface of the substrate, just like the situation in an electrosynthesis. Different from an electrosynthesis where the two electrodes are spatially separated by an electrolyte solution, the cathodes and anodes are situated on the same surface, albeit at different sites, even for a micro/nanostructured substrate. Since the oxidation and dissolution reactions occur at sites different from those for reduction and deposition reactions, one can control the growth pattern of the newly deposited atoms on the same surface of a substrate to access nanostructured materials with diverse and controllable compositions, shapes, and morphologies in a single step. Galvanic replacement synthesis has been successfully applied to different types of substrates, including those made of crystalline and amorphous materials, as well as metallic and nonmetallic materials. Depending on the substrate involved, the deposited material can take different nucleation and growth patterns, resulting in diverse but well-controlled nanomaterials sought for a variety of studies and applications. In this Account, we recapitulate our efforts over the past two decades in fabricating metal nanostructures for a broad range of applications by leveraging the unique capability of galvanic replacement synthesis. We begin with a brief introduction to the fundamentals of galvanic replacement between metal nanocrystals and salt precursors, followed by a discussion of the roles played by surface capping agents in achieving site-selected carving and deposition for the fabrication of various bimetallic nanostructures. Two examples based on the Ag–Au and Pd–Pt systems are selected to illustrate the concept and mechanism. We then highlight our recent work on the galvanic replacement synthesis involving nonmetallic substrates, with a focus on the protocol, mechanistic understanding, and experimental control for the fabrication of Au- and Pt-based nanostructures with tunable morphologies. Finally, we showcase the unique properties and applications of nanostructured materials derived from galvanic replacement reactions for biomedicine and catalysis. We also offer some perspectives on the challenges and opportunities in this emerg...

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Section: Key Referencesmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Nonmetallic Substratesmentioning

confidence: 99%

Section: Key Referencesmentioning

confidence: 99%

Section: Nonmetallic Substratesmentioning

confidence: 99%

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Galvanic Replacement Synthesis of Metal Nanostructures: Bridging the Gap between Chemical and Electrochemical Approaches

et al. 2023

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Epi‐Endocytic Performance Engineering through Nanomaterials Co‐Challenging: A Study of Mechanism and Implication in Radiotherapy

Zhao,

Zheng,

et al. 2024

Adv Funct Materials

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While the influence of size on nanomaterial uptake has been extensively explored, it remains elusive how cells simultaneously respond to multiple, size‐varying particles due to the lack of a proper quantitative assay. In this study, a strategy named “metal‐doping engineering” is developed, and constructed a library of multi‐elemental alloys (MEAs) features precisely controlled size and dopant dosage for quantification with mass spectra. Next a comprehensive study of cellular uptake behaviors is conducted when treated with dual‐, triple‐, and quadra‐, size‐differing nanoparticles. Specifically, the exposure to triple‐, and quadra‐, size‐differing MEAs resulted in an unprecedented, enhanced uptake of counterpart in the middle size as 10/20 nm. Further efforts including RNA‐sequencing and photo‐affinity labeling‐assisted proteomics are devoted to uncovering the underlying mechanism, wherein the role of nonconical endocytic pathways in fast‐endophilin‐mediated endocytosis is uncovered. Given the capacity of MEAs as chaperones to facilitate the uptake of one featuring a predetermined size promoted to propose a straightforward, “bystander nanomaterials”‐assisted drug delivery strategy, whose superior dosage‐reduced radio‐sensitization performance and anti‐tumoral outcome are confirmed in vivo.

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Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

Xia,

Zhou,

et al. 2024

Angewandte Chemie

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Controlling the nanoparticle‐cell membrane interaction to achieve easy and fast membrane anchoring and cellular internalization is of great importance in a variety of biomedical applications. Here we report a simple and versatile strategy to maneuver the nanoparticle‐cell membrane interaction by creating a tunable hydrophobic protrusion on Janus particles through swelling‐induced symmetry breaking. When the Janus particle contacts cell membrane, the protrusion will induce membrane wrapping, leading the particles to docking to the membrane, followed by drawing the whole particles into the cell. The efficiencies of both membrane anchoring and cellular internalization can be promoted by optimizing the size of the protrusion. In vitro, the Janus particles can quickly anchor to the cell membrane in 1 h and be internalized within 24 h, regardless of the types of cells involved. In vivo, the Janus particles can effectively anchor to the brain and skin tissues to provide a high retention in these tissues after intracerebroventricular, intrahippocampal, or subcutaneous injection. This strategy involving the creation of a hydrophobic protrusion on Janus particles to tune the cell‐membrane interaction holds great potential in nanoparticle‐based biomedical applications.

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Controlling the Nucleation and Growth of Au on a-Se Nanospheres to Enhance Their Cellular Uptake and Cytotoxicity

Cited by 14 publications

References 37 publications

Galvanic Replacement Synthesis of Metal Nanostructures: Bridging the Gap between Chemical and Electrochemical Approaches

Galvanic Replacement Synthesis of Metal Nanostructures: Bridging the Gap between Chemical and Electrochemical Approaches

Epi‐Endocytic Performance Engineering through Nanomaterials Co‐Challenging: A Study of Mechanism and Implication in Radiotherapy

Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

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