Autogenic processes are widely found in various sedimentary systems and they play an important role in the depositional evolution and corresponding sedimentary architecture. However, autogenic processes are often affected by changing allogenic factors and are difficult to be identified and analyzed from modern and ancient records. Through the flume tank experiment under constant boundary conditions, the depositional process, evolution principles, and the sedimentary architecture of a river-dominated delta was presented, and a corresponding sedimentary architecture model was constructed. The evolution of river-dominated delta controlled only by autogenic process is obviously periodic, and each autogenic cycle can be divided into an initial progradational stage, a middle retrogratational stage, and a late aggradational–progradational stage. In the initial progradational stage, one feeder channel incised into the delta plain, mouth bar(s) was formed in front of the channel mouth, and small-scale crevasse splays were formed on the delta plain. In the middle retrogradational stage, the feeder channel was blocked by the mouth bar(s) which grew out of water at the end of the initial stage, and a set of large-scale distributary splay complexes were formed on the delta plain. These distributary splay complexes were retrogradationally overlapped due to the continuous migration of the bifurcation point of the feeder channel. In the late aggradational–progradational stage, the feeder channel branched into several radial distributary channels, overlapped distributary channels were formed on the delta plain, and terminal lobe complexes were formed at the end of distributary channels. The three sedimentary layers formed in the three stages constituted an autogenic succession. The experimental delta consisted of six autogenic depositional successions. Dynamic allocation of accommodation space and the following adaptive sediments filling were the two main driving factors of the autogenic evolution of deltas.