Controversial aspects of adverse reactions to food

Ortolani, Claudio; Bruijnzeel-Koomen, Carla A.F.M.; Bengtsson, Ulf; Bindslev‐Jensen, Carsten; Björkstén, Bengt; Høst, Arne; Ispano, Marco; Jarish, R.; Madsen, Charlotte Bernhard; Nékám, K; Paganelli, Roberto; Poulsen, Lars K.; Wüthrich, B

doi:10.1034/j.1398-9995.1999.00913.x

Cited by 114 publications

(36 citation statements)

References 143 publications

(131 reference statements)

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“…Still, it is possible that the intestinal responses we observed were the results of an unspecific, non-immune-mediated defence mechanism [3]. The DBPCFC, which at present is considered to be the ‘golden standard’ for diagnosing FH [15], is of no use in discriminating between non-IgE-mediated food allergy and non-immune-mediated (non-allergic) FH. These reactions are all characterised by positive DBPCFC, but negative SPT and/or food-specific IgE results, and at present we have no adequate diagnostic tools at hand that can help us specify the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Food Hypersensitivity Reactions Visualised by Ultrasonography and Magnetic Resonance Imaging in a Patient Lacking Systemic Food-Specific IgE

et al. 2006

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Background: Abdominal complaints related to food intake might be due to hypersensitivity. A firm diagnosis of food allergy is often difficult to establish, particularly in the absence of systemic food-specific IgE. Using ultrasonography and magnetic resonance imaging (MRI) we were able to visualise the intestinal response in one such case. Methods: A 24-year-old female presented with self-reported food hypersensitivity, particularly related to the intake of egg. Nausea and diarrhoea were predominant symptoms. Double-blind placebo-controlled food challenge with raw egg was positive, but all other conventional tests of food hypersensitivity, including skin prick test, total and food-specific IgE in serum, were negative. A thorough investigation programme could not reveal any organic disease of the gastrointestinal tract. We extended the evaluation to include two new provocation tests, where intestinal wall thickening and the amount of luminal liquid were monitored by external abdominal ultrasound and MRI. Results: Both ultrasound and MRI investigations indicated intestinal wall thickening and influx of large amounts of fluid into the proximal small intestines within 10 min of duodenal challenge with egg. The response was associated with abdominal pain and bloating. Conclusions: The response to provocation was typical of an immediate allergic reaction. Our results indicate that local food-induced hypersensitivity reactions can occur in the gut in the absence of systemic indications of IgE-mediated allergy. Abdominal ultrasonography and MRI might become valuable tools for documenting such responses.

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Section: Discussionmentioning

confidence: 99%

Food Hypersensitivity Reactions Visualised by Ultrasonography and Magnetic Resonance Imaging in a Patient Lacking Systemic Food-Specific IgE

et al. 2006

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“…The reported increase in QoL may equate to increased productivity, less absentteeism from work, less utilization of medical specialists, and an overall reduction on the economic burden of this disease. Although IgE testing is the most commonly recognized method to determine food hypersensitivity [22,23], the use of IgG testing may also be useful in identifying foods that are reactive [21,24]. Despite their potential usefulness as a clinical tool, the medical community does not universally accept the use of IgG-mediated testing since IgG has been found in healthy individuals after ingestion of foods [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Improving quality of life in self-reported gastrointestinal disorders: An open trial of a food elimination diet guided by the ImmunoBloodprint food sensitivity test

Woolger¹,

Lopez²,

Melillo³

et al. 2013

OJIM

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“…No provocation test with food additives should then be performed (16). These patients, after an adequate period (at least one month) of additive free intake, should undergo the reintroduction of the forbidden foods and the administration of anti HI antihistamine drugs on demand.…”

Section: Additive-free Diet According To Freedman and Co-workersmentioning

confidence: 99%

Diagnostic and TherapeuticIterin Chronic Urticaria Patients

Tosoni

Cinquini

2006

Int J Immunopathol Pharmacol

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We describe a diagnostic and therapeutic protocol for the management of chronic urticaria. It is derived from an extensive review of current literature, with a cost-effective evaluation of laboratory investigations and therapeutic approaches. Our protocol may not represent a cornerstone for chronic urticaria: much has in fact to be clarified on pathogenetic mechanisms and aetiological factors. Nevertheless, its application should be able, in our opinion, to identify what is useful or not in the everyday management of chronic urticaria patients.

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Controversial aspects of adverse reactions to food

Cited by 114 publications

References 143 publications

Food Hypersensitivity Reactions Visualised by Ultrasonography and Magnetic Resonance Imaging in a Patient Lacking Systemic Food-Specific IgE

Food Hypersensitivity Reactions Visualised by Ultrasonography and Magnetic Resonance Imaging in a Patient Lacking Systemic Food-Specific IgE

Improving quality of life in self-reported gastrointestinal disorders: An open trial of a food elimination diet guided by the ImmunoBloodprint food sensitivity test

Diagnostic and TherapeuticIterin Chronic Urticaria Patients

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