Controversies and recommendations regarding sentinel lymph node biopsy in primary breast cancer: A comprehensive review of current data

Charalampoudis, Petros; Markopoulos, Christos; Kovács, Tibor

doi:10.1016/j.ejso.2017.10.215

Cited by 39 publications

(34 citation statements)

References 79 publications

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“…Sentinel lymph node biopsy (SLNB) is used to stage the axilla in breast cancer patients with negative preoperative staging, and guides local and systemic treatment . Patients with positive sentinel nodes may require chemotherapy and axillary treatment with either surgical clearance or axillary radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

The role of sentinel lymph node biopsy in planning adjuvant therapy for elderly women with low‐risk breast cancer

et al. 2019

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Sentinel lymph node biopsy (SLNB) guides adjuvant therapy in breast cancer. There is controversy regarding its use in elderly women with low-risk breast cancer. This study aimed to determine whether a positive SLNB in this group affected the decision to offer adjuvant therapy compared with younger patients. This retrospective review included 492 patients, 89 of whom had a positive SLNB. Elderly, node-positive women were significantly less likely to receive chemotherapy than their younger counterparts (P < .0001), suggesting the use of SLNB in the elderly could be rationalized. K E Y W O R D Sadjuvant therapy, breast cancer, chemotherapy, elderly, node positivity, sentinel lymph node biopsy

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Section: Introductionmentioning

confidence: 99%

The role of sentinel lymph node biopsy in planning adjuvant therapy for elderly women with low‐risk breast cancer

et al. 2019

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“…Performing axillary lymph node dissection as a substitute for sentinel lymph node biopsy even in the absence of radioisotope is no longer accepted. This explains the need for providing other effective alternatives for SLN detection in areas lacking availability of radioisotopes …”

Section: Discussionmentioning

confidence: 99%

Preoperative localization of sentinel lymph node in breast cancer patients by silver wire insertion or liquid charcoal injection guided by CT lymphography

et al. 2019

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Dual localization of SLN in breast cancer patients using isotope & dye is the best‐approved modality with limitations such as high cost of radioactive materials, complex logistic preparations & scheduling issues, especially in developing countries. We investigated the feasibility & accuracy of a novel technique for SLN localization using silver wire insertion or liquid charcoal injection guided by CT lymphography. 120 patients with clinically node‐negative breast cancer were enrolled. In the test group, SLN was localized using preoperative CTLG guided injection of liquid charcoal or by placing a 3 cm silver wire. In addition, intraoperative SLN mapping was performed using methylene blue dye followed by searching for the SLN localized by both methods. In the control group, SLN was localized by the blue dye only. Feasibility, accuracy, detection rates, and number of SLNs retrieved were reported as well as matching between the LN detected with the CTLG and that detected with the dye technique. SLN could be detected in 59 out of 60 patients (98.3%) in the test group and in 54 out of 60 patients (90%) in the control group (P = .057). In self‐controlled analysis of the test group comparing CTLG only to dye only was significant (P = .050). Comparing charcoal to silver wire in detection was statistically insignificant (P = .5). This novel method can offer advantages which are as follows: being more accurate than the dye alone, saving operative time, abandoning complex logistic preparations for the radioisotope, and solving the problem of timing.

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“…As in melanoma, sentinel lymph node mapping is considered the gold standard for staging of the axilla in breast carcinoma 12 13. The greater incidence of breast cancer, compared with other tumor types, has led to a vastly increased experience with sentinel lymph node mapping and the establishment of prognostically relevant groups based on metastasis size.…”

Section: Sentinel Lymph Node Mapping: the Melanoma And Breast Cancer mentioning

confidence: 99%

Pathology of sentinel lymph nodes: historical perspective and current applications in gynecologic cancer

Euscher

2020

Int J Gynecol Cancer

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Efforts to reduce surgical morbidity related to en bloc lymph node removal associated with cancer surgery led to the development of targeted lymph node sampling to identify the lymph node(s) most likely to harbor a metastasis. Through identification of one or only a few lymph nodes at highest risk, the overall number of lymph nodes removed could be markedly reduced. Submission of fewer lymph nodes affords more detailed pathologic examination than would otherwise be practical with a standard lymph node dissection. Such enhanced pathologic examination techniques (ie, ultra-staging) have contributed to increased detection of lymph node metastases, primarily by detection of low volume metastatic disease. Based on the success of sentinel lymph node mapping and ultra-staging in breast cancer and melanoma, such techniques are increasingly used for other organ systems including the gynecologic tract. This review addresses the historical aspects of sentinel lymph node evaluation and reviews current ultra-staging protocols as well as the implications associated with increased detection of low volume metastases.

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Controversies and recommendations regarding sentinel lymph node biopsy in primary breast cancer: A comprehensive review of current data

Cited by 39 publications

References 79 publications

The role of sentinel lymph node biopsy in planning adjuvant therapy for elderly women with low‐risk breast cancer

The role of sentinel lymph node biopsy in planning adjuvant therapy for elderly women with low‐risk breast cancer

Preoperative localization of sentinel lymph node in breast cancer patients by silver wire insertion or liquid charcoal injection guided by CT lymphography

Pathology of sentinel lymph nodes: historical perspective and current applications in gynecologic cancer

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