Controversies in hair transplantation

Kumaresan, M; Mysore, Venkatram

doi:10.4103/jcas.jcas_118_18

Cited by 17 publications

(11 citation statements)

References 26 publications

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“…Among the currently accessible methods of AGA treatment, transplantation is considered to be the conventional technique, e.g., platelet-rich plasma therapy, follicular unit extraction, and strip harvesting. However, the effectiveness still needs to be studied properly [ 119 ]. In several topical and oral medications, minoxidil has already been widely used as a hair loss remedy.…”

Section: Available and Recently Studied Therapeutics For Agamentioning

confidence: 99%

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.

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Section: Available and Recently Studied Therapeutics For Agamentioning

confidence: 99%

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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“…In our study, a U1 degree patient required about 5000-6000 follicular units. Previous studies have shown that surgeons were allowed to remove donor strip with maximum width of 2 cm and maximum length of 30 cm in FUT, 15,16 indicating the maximum area of donor strip was 60 cm 2 . As the average hair density of Asian scalp is 75 FU/ cm 2 , 17 the maximum number of follicular graft is about 4500 grafts in a single session via FUT (strip) method, which is less than the quantity requirement of graft in U1 degree patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical experience on follicular unit extraction megasession for severe androgenetic alopecia

Wang

et al. 2019

J of Cosmetic Dermatology

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Background Severe androgenetic alopecia has significant impact on patients’ self‐image and emotional health. As the most advanced way to achieve the growth of a full head of hair in shortest period of time, the megasession hair transplant procedure is a promising treatment for severe androgenetic alopecia. Aims To introduce the procedure and technical details of follicular unit extraction megasession and to evaluate the surgery outcome. Method A total of 273 male patients undergoing follicular unit extraction (FUE) megasession between 2016 and 2018 were included in our study. The extraction was performed using 1.0 mm punch. The BASP classification degree of patient hair loss, the number of extracted hair, surgery consuming time, and graft survival rate were recorded. We finally evaluated patients’ satisfaction with surgery outcomes. Results Ages of patients ranged from 28 to 53 years, with a mean of 42 years (SD, 8.42). All of them were at C3 and U1 degree of BA type hair loss according to the BASP classification. The number of follicular units transplanted was between 3000 and 6000, with surgery duration range from 6 hours to 12 hours and graft survival rate varies from 93.5% to 96.6%. A total of 81% of them were satisfied with the outcomes, 19% of them had a second procedure performed to provide further hair density. None of them had infection after the surgery. Conclusion Compared with multi‐stage hair transplantation, FUE megasession has the advantages of reducing operation frequency and overall surgery duration. Thus, FUE megasession is an appealing treatment option for severe AGA patients, who expect to a more desirable natural and esthetically pleasing result in a one‐stage operation.

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“…area, encroaching upon the safe donor zone, may influence the identification of the safe donor zone. 6,13,14,21,22,24 Additional donor regions: beard, chest, extremities, and pubis. 6,13,14,18,21,22 Donor area template: This template marks the safe donor zone margins.…”

Section: Concepts Terminology and Innovations In Follicular Unit Exci...mentioning

confidence: 99%

Concepts, Terminology, and Innovations in Follicular Unit Excision Hair Restoration Surgery

Gupta,

Polla Ravi

2023

Facial Plast Surg

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Follicular Unit Excision (FUE) has emerged as the preferred method for hair transplants. Standardized terms and definitions established by members of the International Society of Hair Restoration Surgery (ISHRS) and prominent hair restoration surgeons have become the standard, enabling effective knowledge sharing. This chapter provides an overview of the terminology relating to the field. The historical evolution of follicular unit excision and its pivotal role in modern hair transplantation is summarized. Anatomical terminology and graft-related definitions follow, providing insights into the scalp's complex structures and graft characteristics. The subsequent sections detail the terminology associated with graft excision and extraction, shedding light on the precise techniques and procedures employed. An exploration of various FUE techniques and the evolving landscape of FUE devices underscores the continual refinement of hair restoration practices. The chapter proceeds to discuss the ‘safe’ scalp donor zones, donor assessment terminology, and elements in identifying the optimal donor area for a successful FUE procedure. Additionally, punch dynamics and technique characteristics are examined, emphasizing their pivotal role in achieving superior FUE outcomes. The chapter concludes by discussing the classification of punches and graft evaluation terms, offering insights into the tools and criteria used to assess graft quality and viability.

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Controversies in hair transplantation

Cited by 17 publications

References 26 publications

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Clinical experience on follicular unit extraction megasession for severe androgenetic alopecia

Concepts, Terminology, and Innovations in Follicular Unit Excision Hair Restoration Surgery

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