The scientific community is currently showing strong interest in constructing
knowledge graphs from heterogeneous domains (genomic, pharmaceutical,
clinical etc.). The main goal here is to support researchers in gaining an
immediate overview of the biomedical and clinical data that can be utilized
to construct and extend KGs. A in-depth overview of the available
biomedical data and the latest applications of knowledge graphs, from the
biological to the clinical context, is provided showing the most recent
methods of representing biomedical knowledge with embeddings (KGEs).
Furthermore, this review, differentiates biomedical databases based on their
construction process (whether manually curated by experts or not), aiming to
offer a detailed overview and guide researchers in selecting the
appropriate database for their research considering to the specific project
needs, available resources, and data complexity. In conclusion, the review
highlights current challenges: integration of different knowledge graphs and
the interpretability of predictions of new relations.