Convenient syntheses of new quinoline nucleosides bearing amino acid esters

Ali, Ibrahim A. I.

doi:10.3998/ark.5550190.0009.h07

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…The structural core of quinoline derivatives is frequently associated with medicinal applications, such as anti‐cancer [1], anti‐tumor [2], anti‐bacterial [3], anti‐fungal [4], anti‐malarial [5], anti‐leishmanial [6] activities, and inhibited HIV‐1 [7].…”

Section: Introductionmentioning

confidence: 99%

QSAR studies of quinoline alkaloids camptothecin derivatives for prediction anticancer activity using linear and nonlinear methods

Mohebbi,

Shafiei,

Momeni Isfahani

et al. 2024

Int J of Quantum Chemistry

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Quinoline alkaloid camptothecin (CPT) derivatives are compounds with a wide range of inhibitory activities and they are the basis of several groups of drugs. CPT is one of the prominent lead compounds in anticancer drug development. It inhibits DNA topoisomerase I (topo I) enzyme and has shown remarkable anticancer activity against lung, colon, rectum, ovarian, breast, and stomach cancers. Quantitative structure–activity relationship (QSAR) is basically a statistical approach correlating the response activity data with descriptors encoding chemical information. In the current research, a QSAR study was performed for modeling and predicting the anticancer activity (pIC50) of 76 CPT derivatives as an inhibitor of DNA topo I using the genetic algorithm multiple linear regression (GA‐MLR) and back propagation artificial neural network (BP‐ANN) methods. The results of this study indicate that the use of constitutional and geometrical descriptors provide good estimate for pIC50. The obtained results of statistical criteria, internal and external validation show the superiority of BP‐ANN model than GA‐MLR to predict the pIC50 values of the investigated compounds. QSAR model developed in this study can be used for design and development of novel potent CPT derivatives and for predicting their anticancer activity.

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Section: Introductionmentioning

confidence: 99%

QSAR studies of quinoline alkaloids camptothecin derivatives for prediction anticancer activity using linear and nonlinear methods

Mohebbi,

Shafiei,

Momeni Isfahani

et al. 2024

Int J of Quantum Chemistry

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“…[24][25][26][27][28] Heating chromone-3-carboxylic acid with primary or secondary amines gives rise to a variety of products depending on the solvent used. 29,30 Treatment of chromone-3-carboxamide with nitrogen nucleophilic reagents produced 3-alkylaminomethylenechromane-2,4-diones and coumarins. 31,32 Furthermore, heating chromone-3-carboxylate with concentrated ammonium hydroxide leads to 3-formimidoyl-4-hydroxycoumarin.…”

Section: Introductionmentioning

confidence: 99%

Cascade reactions between 2-substituted-3-(4-oxo-4H-chromen-3-yl)acrylonitriles with benzylamine and p-toluidine

Ibrahim¹,

Badran²

2018

Arkivoc

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Chemical transformations of the simple condensation products derived from 3-formylchromone and some active methylene compounds, was achieved by reaction with nucleophilic reagents namely benzylamine and p-toluidine to produce either 2-iminopyrane or pyrano[3,2-c]chromene derivatives. These transformations initially proceed through nucleophilic attack at C-2 of the γ-pyrone ring with concomitant addition of the carbonyl oxygen onto the nitrile function followed by further transformations depending on the substrate and the nucleophile used. The structures of the new synthesized products were deduced on the basis of their analytical and spectroscopic data.

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Convenient syntheses of new quinoline nucleosides bearing amino acid esters

Cited by 2 publications

References 22 publications

QSAR studies of quinoline alkaloids camptothecin derivatives for prediction anticancer activity using linear and nonlinear methods

QSAR studies of quinoline alkaloids camptothecin derivatives for prediction anticancer activity using linear and nonlinear methods

Cascade reactions between 2-substituted-3-(4-oxo-4H-chromen-3-yl)acrylonitriles with benzylamine and p-toluidine

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