Convenient Synthesis and Characterization of Pyrazolones and Schiff Bases

Girisha, K. S.; Kalluraya, Balakrishna

doi:10.1080/00397911.2011.576323

Cited by 3 publications

(1 citation statement)

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“…5 Similarly, substituted furan/thiophene derivatives also exhibit significant biological activities, such as antibacterial, HIV-1 fusion inhibitions, antitumor, anti-inflammatory and antioxidant properties, etc. [6][7][8][9][10] Prompted by these observations and in continuation of an ongoing search for biologically active heterocycles, [11][12][13][14] the synthesis of a novel series of N-acetyl pyrazoline carrying an arylfuran/arylthiophene moiety is reported herein. These synthesized compounds were evaluated for their antioxidant activity.…”

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confidence: 99%

Synthesis and antioxidant activity study of pyrazoline carrying arylfuran/thiophene moiety

Jois

Kalluraya

Girisha

2014

JSCS

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A novel series of N-acetyl-3-aryl-5-(5-(p/o-nitrophenyl)-2-furyl/ /thienyl)-substituted pyrazolines (3a-o) were synthesized by the reaction of 1-aryl-3-(5-(p/o-nitrophenyl)-2-furyl/thienyl)-2-propene-1-ones with hydrazine hydrate in acetic acid medium. The structures of the newly synthesized compounds were established by IR, 1 H-NMR, mass spectra and a single-crystal X-ray study. The antioxidant activities of the synthesized compounds were determined using the DPPH scavenging assay. The compounds 3a, 3f, 3h and 3o showed moderate activity.

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