Convenient Synthesis of 2-Aryl-1-haloindolizines from Pyridinium Salts and 2-Aryl-1,1-dihaloalk-1-enes

Abstract

2-Aryl-1-haloindolizines were synthesized from pyridinium salts and 2-aryl-1,1-dihaloalk-1-enes using a DBU/THF system. 2-Aryl-1,1-dihaloalk-1-enes containing electron-withdrawing or -donating groups were efficiently converted into the corresponding 2-aryl-1-haloindolizines in moderate to excellent yields.