Convenient synthesis of decalin systems of bioactive terpenoids

Gore, Vinayak K.; Mayelvaganan, T.; Padmakumar, R.; Hadimani, S. B.; Bhat, Sujata V.

doi:10.1016/s0040-4020(01)86353-5

Cited by 9 publications

(1 citation statement)

References 17 publications

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“…Nimbolide has a decalinskeleton [20] and belongs to a group of tetranortriterpenoids called C-secoMeliacins [2]. The 2D chemical structure of nimbolide is illustrated in Figure 2.…”

Section: Chemical Structure and Properties Of Nimbolidementioning

confidence: 99%

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

et al. 2016

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Nimbolide is one of the main components in the leaf extract of Azadirachta indica (A. indica). Accumulating evidence from various in vitro and in vivo studies indicates that nimbolide possesses potent anticancer activity against several types of cancer and also shows potential chemopreventive activity in animal models. The main mechanisms of action of nimbolide include anti-proliferation, induction of apoptosis, inhibition of metastasis and angiogenesis, and modulation of carcinogen-metabolizing enzymes. Although multiple pharmacodynamic (PD) studies have been carried out, nimbolide is still at the infant stage in the drug development pipeline due to the lack of systematic pharmacokinetic (PK) studies and long-term toxicological studies. Preclinical PK and toxicological studies are vital in determining the dosage range to support the safety of nimbolide for first-in-human clinical trials. In this review, we will provide a comprehensive summary for the current status of nimbolide as an anticancer and chemopreventive lead compound, and highlight the importance of systematic preclinical PK and toxicological studies in accelerating the process of application of nimbolide as a therapeutic agent against various malignancies.

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“…Nimbolide has a decalinskeleton [20] and belongs to a group of tetranortriterpenoids called C-secoMeliacins [2]. The 2D chemical structure of nimbolide is illustrated in Figure 2.…”

Section: Chemical Structure and Properties Of Nimbolidementioning

confidence: 99%

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

et al. 2016

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Extrusion Reactions Affording Aromatic Systems, Dienes and Polyenes

Guziec

2022

Organic Reactions

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Extrusion reactions may be defined as chemical reactions in which an atom or small molecular fragment Y connected to two other atoms W and Z is lost from a molecule, leading to a product in which W becomes directly bonded to Z. Cheletropic reactions that afford aromatic or conjugated π systems by loss of a stable atomic or molecular fragment have also been classified as extrusion reactions. Typically, the fragments liberated in these reactions are small, stable inorganic molecules or atoms such as carbon monoxide, carbon dioxide, sulfur, sulfur monoxide, sulfur dioxide, selenium, tellurium, oxygen and nitrogen. This chapter primarily deals with the synthesis of arenes, heterocycles, 1,3‐dienes and polyenes using such extrusion processes. The utility of these reactions in the synthesis of sterically hindered molecules, dendrimers, pheromones, and other natural products are highlighted. The use of extrusion reactions for the “Click and Release” approach in drug development is also introduced.

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