2014
DOI: 10.1016/j.tetlet.2014.10.005
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Convenient synthesis of N1-substituted orotic acid derivatives

Abstract: A convenient and efficient method for the synthesis of N1-substituted orotic acid derivatives is reported. The synthetic route utilizes substituted maleimide as synthetic intermediate and takes only four simple steps from readily available starting materials. As a result, orotic acid derivatives with various alkyl and aromatic groups at N1 can be readily synthesized.

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Cited by 7 publications
(1 citation statement)
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“…10 The method starts with the reaction of an amine (e.g., aniline, benzyl amine, or cyclohexyl amine) with a mixture of cis - and trans -2,3-dibromosuccinimide (1) in THF at room temperature to yield 2-arylaminoaminomaleimide (2) via a tandem dehydrobromination-conjugate addition-elimination mechanism, as shown in Scheme 1.…”
Section: Resultsmentioning
confidence: 99%
“…10 The method starts with the reaction of an amine (e.g., aniline, benzyl amine, or cyclohexyl amine) with a mixture of cis - and trans -2,3-dibromosuccinimide (1) in THF at room temperature to yield 2-arylaminoaminomaleimide (2) via a tandem dehydrobromination-conjugate addition-elimination mechanism, as shown in Scheme 1.…”
Section: Resultsmentioning
confidence: 99%