Convenient synthesis of novel pyrimido[4,5‐b][1,5]benzothiazepines

Abstract

Reaction of 4,6-dichloropyrimidine-5-carbaldehyde with amines in chloroform gave 4-(substitutedamino)-6-chloro-pyrimidine-5-carbaldehydes derivatives at low temperature. Treatment of the latter products with 2-aminobenzenethiol in alkaline benzene and then in boiling acetonitrile gave a novel group of 11Hpyrimido[4,5-b][1,5]benzodiazepine derivatives. Structures of the products confirmed by 1 HNMR, IR, and mass spectra.