Abstract:Racemic quebrachamine (1) has been synthesised from 2‐hydroxytryptamine and dimethyl 4‐ethyl‐4‐formylpimelate through 1,2‐dehydroaspidospermidine (8), obtained by selective reduction of the carbonyl function of lactam 3.
Aus dem nach bekannten Verfahren hergestellten Lactam (Ia) entsteht über die Schwefelverbindung (Ib) und das Acetylierungsprodukt (IIa) die entschwefelte Verbindung (IIb), die nach Hydrolyse zu (III) in D,L‐Quebrachin (IV) übergeht.
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