Conventional and microwave prompted synthesis, antioxidant, anticholinesterase activity screening and molecular docking studies of new quinolone-triazole hybrids

Mermer, Arif; Demirbaş, Neslihan; Şirin, Yakup; Uslu, Harun; Özdemi̇r, Zeynep; Demırbas, Ayhan

doi:10.1016/j.bioorg.2018.03.017

Cited by 43 publications

(25 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Free radicals emit from the environment either from chain reactions of free radicals or from numerous ordinary biological processes, in vivo . Their reactions are started constantly in the body from enzymatic (those involved in cytochrome P450, phagocytosis and biosynthesis of prostaglandin) and non-enzymatic (those started by ionizing radiation) reactions (Halliwell, 1994, Beckman and Ames, 1998, Mermer et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study

Almehizia

Abuelizz

Taie

et al. 2019

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Previously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1–16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1–16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity. The butylated hydroxyl toluene (BHT) used as standard agent.Density functional theory was carried out to explain the relative importance of CO, CS and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents.

show abstract

Section: Introductionmentioning

confidence: 99%

Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study

Almehizia

Abuelizz

Taie

et al. 2019

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…They are considered bioisosteres of the chromen-4-one scaffold and exist in equilibrium with its tautomeric form i. e. 4-hydroxyquinoline (figure 1). [1] They are known to possess a broad range of biological activities which includes antimicrobial, [2,3] antiviral, [4][5] antiplasmodial, [6] antioxidant, [7] anti-inflammatory, [8] anticholinesterase, [9] anticonvulsant, [10] anticancer, [11] neuroprotective, [12] genitourinary infections, [13] prostatitis, respiratory diseases, as well as skin and soft tissue infections. [14][15] In addition to the above, now they are widely explored as anti-HIV, [16] antimalarial agents, [17,18] alkaline phosphatase inhibitors, [19] antifilarial agents, [20] and antidiabetic agent, [21] for the development of novel therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in the Synthetic Strategies of 4‐Quinolones and Its Derivatives

2020

View full text Add to dashboard Cite

The ubiquitous presence of 4-quinolones and its derivatives in a wide range of natural as well as synthetic drug molecules made them molecule of utmost importance for organic and medicinal chemists. Their wide array of biological activities such as antimicrobial, anticancer, anti-HIV, genitourinary infection, antifilarial, etc., has augmented their appeal both for synthetic and medicinal chemistry campaigns. Moreover, they are valuable intermediates for the synthesis of various fused heterocyclic compounds of synthetic and medicinal importance. Considering their array of synthetic and biological importance, new strategies for the synthesis of 4-quinolones and their derivatives have been designed and successfully demonstrated by researchers around the globe. The present review covers recent advances in the synthetic chemistry of 4quinolones since 2015 along with an insight into their mechanistic studies. We hope that the review article will serve as a valuable tool for the scientific community engaged in the synthesis and utilization of 4-quinolones and their derivatives.

show abstract

“…Quinolones (including 2‐quinolones and 4‐quinolones) possess diverse pharmacological properties, such as antibacterial, antimalarial, antitubercular, anticancer, anti‐Alzheimer's disease, antifungal, anti‐HCV, and anti‐HIV activities, playing an intriguing role in the development of new drugs. Elvitegravir (Figure ), the first quinolone integrase inhibitor, has already been approved by the U.S. Food and Drug Administration for the treatment of HIV infection, demonstrating that quinolone derivatives might have potential anti‐HIV activity …”

Section: Introductionmentioning

confidence: 99%

Quinolone derivatives: Potential anti‐HIV agent—development and application

Wang

Shi

2019

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

Conventional and microwave prompted synthesis, antioxidant, anticholinesterase activity screening and molecular docking studies of new quinolone-triazole hybrids

Cited by 43 publications

References 50 publications

Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study

Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study

Recent Developments in the Synthetic Strategies of 4‐Quinolones and Its Derivatives

Quinolone derivatives: Potential anti‐HIV agent—development and application

Contact Info

Product

Resources

About