Conventional and nanotechnology based sensors for creatinine (A kidney biomarker) detection: A consolidated review

Babu, Punuri Jayasekhar; Tirkey, Akriti; Rao, T. J.; Chanu, Naorem Bidyaleima; Lalchhandama, Kholhring; Singh, Yengkhom Disco

doi:10.1016/j.ab.2022.114622

Cited by 30 publications

(14 citation statements)

References 87 publications

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“…The development and application of modified electrodes with various materials have made the field of electrochemical sensor research flourish [ 29 , 30 ]. Many electrochemical sensors have been developed for the determination of uric acid and creatinine [ 31 , 32 , 33 , 34 ]. Among these electrochemical biosensors, non-enzymatic sensors have gained much attention due to their low-cost, simplicity, accuracy and portability [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Sensitivity Detection of Uric Acid and Creatinine in Human Urine Based on Nanoporous Gold

et al. 2022

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Given the significance of uric acid and creatinine in clinical diagnostic, disease prevention and treatment, a multifunctional electrochemical sensor was proposed for sensitive detection of uric acid and creatinine. The sensitive detection of uric acid was realized based on the unique electrochemical oxidation of nanoporous gold (NPG) towards uric acid, showing good linearity from 10 μM to 750 μM with a satisfactory sensitivity of 222.91 μA mM−1 cm−2 and a limit of detection (LOD) of 0.06 μM. Based on the Jaffé reaction between creatinine and picric acid, the sensitive detection of creatinine was indirectly achieved in a range from 10 to 2000 μM by determining the consumption of picric acid in the Jaffé reaction with a detection sensitivity of 195.05 μA mM−1 cm−2 and a LOD of 10 μM. For human urine detection using the proposed electrochemical sensor, the uric acid detection results were comparable to that of high-performance liquid chromatography (HPLC), with a deviation rate of less than 10.28% and the recoveries of uric acid spiked in urine samples were 89~118%. Compared with HPLC results, the deviation rate of creatinine detection in urine samples was less than 4.17% and the recoveries of creatinine spiked in urine samples ranged from 92.50% to 117.40%. The multifunctional electrochemical sensor exhibited many advantages in practical applications, including short detection time, high stability, simple operation, strong anti-interference ability, cost-effectiveness, and easy fabrication, which provided a promising alternative for urine analysis in clinical diagnosis.

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Section: Introductionmentioning

confidence: 99%

Sensitivity Detection of Uric Acid and Creatinine in Human Urine Based on Nanoporous Gold

et al. 2022

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“…where the major focus is given on the nonclinical biomarkers such as NAG, NGAL, KIM-1, and interleukin-18 (IL-18), cystatin C, β-2microglobulin, L-FABP, and so forth, (Derin & Inci, 2022). In another review by Jayasekhar Babu et al (2022) the major discussion is based on the creatinine biosensors advancement based on nanotechnology tools (Jayasekhar Babu et al, 2022). Although these reviews are important, they have been focused either on various nonclinical molecules or on nearly a single type of CKD biomarker.…”

Section: Introductionmentioning

confidence: 99%

“…In another review by Jayasekhar Babu et al. (2022) the major discussion is based on the creatinine biosensors advancement based on nanotechnology tools (Jayasekhar Babu et al, 2022). Although these reviews are important, they have been focused either on various nonclinical molecules or on nearly a single type of CKD biomarker.…”

Section: Introductionmentioning

confidence: 99%

Design and development of opto‐electrochemical biosensing devices for diagnosing chronic kidney disease

Kumar

Darshna

Sammi

et al. 2023

Biotech & Bioengineering

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Chronic kidney disease (CKD) is emerging as one of the major causes of the increase in mortality rate and is expected to become 5th major cause by 2050. Many studies have shown that it is majorly related to various risk factors, and thus becoming one of the major health issues around the globe. Early detection of renal disease lowers the overall burden of disease by preventing individuals from developing kidney impairment. Therefore, diagnosis and prevention of CKD are becoming the major challenges, and in this situation, biosensors have emerged as one of the best possible solutions. Biosensors are becoming one of the preferred choices for various diseases diagnosis as they provide simpler, cost‐effective and precise methods for onsite detection. In this review, we have tried to discuss the globally developed biosensors for the detection of CKD, focusing on their design, pattern, and applicability in real samples. Two major classifications of biosensors based on transduction systems, that is, optical and electrochemical, for kidney disease have been discussed in detail. Also, the major focus is given to clinical biomarkers such as albumin, creatinine, and others related to kidney dysfunction. Furthermore, the globally developed sensors for the detection of CKD are discussed in tabulated form comparing their analytical performance, response time, specificity as well as performance in biological fluids.

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“…These reasons make it difficult to popularize the detection of creatinine by HPLC 9,12,13 . One of the main trends in detecting creatinine is by enzyme binding other sensors, and the enzyme system becomes the more reported creatinine sensor due of its high selectivity [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Taper-in-taper fiber structure-based biosensor for diagnosis of kidney failure

Liu,

Singh,

Zhang

et al. 2023

Advanced Sensor Systems and Applications XIII

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Creatinine is a metabolite of human muscles that can be used to infer whether part of the kidneys is functioning properly.In this paper, a taper-in-taper fiber (TITF) based fiber optic biosensor is proposed for detecting the concentrations of creatinine solution and helps to diagnosis of kidney failure. The TITF structure used in this study is formed by fabricating a taper shape again in the tapered region of a normal taper optical fiber. This allows the fiber to produce more higher-order modes and thus improve its ability to sense changes in refractive index of the external environment. The sensitivity of the sensor was increased by coating the tapered region of the TITF fiber with a gold nanoparticles and zinc oxide nanomaterials.Creatinase enzyme is used to increase the specificity of the sensor for creatinine. The experimental results show that the sensor can detect the creatinine solution with the concentrations of 300-2000 μM and the sensitivity is 0.17 a.u./μM. It provides a good choice for biomedical applications.

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Conventional and nanotechnology based sensors for creatinine (A kidney biomarker) detection: A consolidated review

Cited by 30 publications

References 87 publications

Sensitivity Detection of Uric Acid and Creatinine in Human Urine Based on Nanoporous Gold

Sensitivity Detection of Uric Acid and Creatinine in Human Urine Based on Nanoporous Gold

Design and development of opto‐electrochemical biosensing devices for diagnosing chronic kidney disease

Taper-in-taper fiber structure-based biosensor for diagnosis of kidney failure

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