2022
DOI: 10.1038/s41598-022-25917-5
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Conventional and synchronous spectrofluorometric determination of the recently administered drugs for treatment of COVID-19 favipiravir and apixaban

Abstract: COVID-19 is a fast-spreading pandemic that is caused by SARS-CoV-2 viral pathogen. Combination therapy of the antiviral favipiravir and the anticoagulant apixaban is one of the efficient treatment regimens. Therefore, development of novel and sensitive methods for simultaneous analysis of such combination is highly advantageous. Herein, two eco-friendly, simple, rapid, and cost-effective spectrofluorometric methods were evolved for the estimation of favipiravir and apixaban in pharmaceutical and biological mat… Show more

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Cited by 5 publications
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“…Thus, the development of a reliable method for the analysis of pharmaceuticals and biological fluids for the determination of FAV is of importance for both scientific and therapeutic reasons. Spectrofluorimetry, [7] chromatography [8] and electrochemistry [2,9,10] have been performed for the determination of FAV in pharmaceuticals and fluids. Of the analytical techniques, electrochemistry enables high accuracy and excellent precision for the determination of antiviral drugs such as adefovir and tenofovir without the requirement of an extraction step [11–17] .…”
Section: Introductionmentioning
confidence: 99%
“…Thus, the development of a reliable method for the analysis of pharmaceuticals and biological fluids for the determination of FAV is of importance for both scientific and therapeutic reasons. Spectrofluorimetry, [7] chromatography [8] and electrochemistry [2,9,10] have been performed for the determination of FAV in pharmaceuticals and fluids. Of the analytical techniques, electrochemistry enables high accuracy and excellent precision for the determination of antiviral drugs such as adefovir and tenofovir without the requirement of an extraction step [11–17] .…”
Section: Introductionmentioning
confidence: 99%