Conventional cancer treatment alone or with regional hyperthermia for pain relief in lung cancer: A case–control study

Kim, Yeon-Pyo; Choi, Yuri; Kim, Sun; Park, Yoon-Sung; Oh, In Jae; Kim, Kyu‐Sik; Kim, Young‐Chul

doi:10.1016/j.ctim.2015.04.004

Cited by 6 publications

(10 citation statements)

References 26 publications

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“…Most patients reported better QoL (evaluated by subjective responses as during follow-up visits) in arm A Related to EH: (according to CTCAE, n = 50) Headache: n = 1 (2%) Scalp burn n = 1 (2%) Seizures n = 5 (10%) (all patients experienced this symptom from the beginning of disease. Seizure during EH in n = 1) Kim et al [ 57 ] Arm A: EH (EHY2000, Oncotherm) + conventional cancer treatment (after PSM: n = 35, at BL: n = 32) Arm B: Conventional cancer treatment alone (after PSM: n = 175, at BL: n = 83) Type of cancer: Lung cancer Duration target temp. per session: 39–42 °C for 60 min Numbers of treatment sessions: 1–47 (mean: 19.3) Treatment durations: 1–42 weeks (mean: 10.3 weeks) Period of time: 2010–2013 1.…”

Section: Resultsmentioning

confidence: 99%

“…In this retrospective cohort study by Kim et al [ 57 ], the intervention group was treated additionally with EH (EHY2000, Oncotherm) two to three times (estimated 39–42 °C for about 60 min). Data collection was carried out at four different time points during 180 days after the start of the study.…”

Section: Resultsmentioning

confidence: 99%

“…In the RCT by Minnaar et al [ 51 ], adipose tissue burns occurred in 9.5% and pain in 9% of patients treated with EH. In the cohort study by Kim et al [ 57 ] in the first 60 days after treatment, a significantly higher opioid dose was used in the group treated with hyperthermia ( p = 0.022). Comparing the arms in the RCT by Loboda et al [ 54 ] which included treatment with and without EH, there were no differences in haematological and gastrointestinal toxicities or liver and kidney function.…”

Section: Resultsmentioning

confidence: 99%

“…In the retrospective cohort study by Kim et al [ 57 ] the EAS over the time showed worse values in the EH group and a significant higher opioid dose within the first 60 days. In another retrospective cohort study by Kim et al [ 58 ] treating the intervention group with EH, no significant difference was found in the pathologic outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Provider of alternative hyperthermia concepts also advertise with the same mentioned theoretical principles, but the implementation of uniform rules is missing. In the present review, information about temperature measurements is lacking in 15 studies [ 46 , 50 , 55 , 57 , 58 , 64 , 81 , 82 , 84 , 85 , 87 , 94 – 97 ]. In the studies by Minnaar et al [ 51 – 53 ], the authors do not consider it necessary to measure the temperature.…”

Section: Discussionmentioning

confidence: 99%

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Systematic review about complementary medical hyperthermia in oncology

et al. 2022

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Hyperthermia is a generic term for different techniques using heat in cancer therapies. Temperatures of about 42° Celsius in combination with chemo- or radiotherapy may improve the effectiveness of those treatments. Clinical benefit is shown in “standard hyperthermia” with tumour temperatures assessed during treatment. This systematic review thoroughly assesses the state of evidence concerning the benefits and side effects of electro hyperthermia or whole-body hyperthermia (“alternative hyperthermia”) in oncology. From 26 April 2021 to 09 May 2021, a systematic search was conducted searching five electronic databases (Embase, Cochrane, PsycINFO, CINAHL and Medline) to find studies concerning the use, effectiveness and potential harm of alternative medical hyperthermia therapy on cancer patients. From all 47,388 search results, 53 publications concerning 53 studies with 2006 patients were included in this systematic review. The patients were diagnosed with different types of cancer. The hyperthermic methods included whole-body hyperthermia (WBH) with different methods and electro hyperthermia (EH). The majority of the included studies were single-arm studies, counting in total 32 studies. Six studies were randomized controlled trials (RCT). In addition, one systematic review (SR) was found. The most critical endpoints were tumour response, survival data, pain relief, myelosuppression and toxicities. Outcome was heterogeneous, and considering the methodological limitations, clinical evidence for the benefit of alternative hyperthermia in cancer patients is lacking. Neither for whole-body hyperthermia nor for electro hyperthermia there is any evidence with respect to improvement of survival or quality of life in cancer patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review about complementary medical hyperthermia in oncology

et al. 2022

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Zentrale Empfehlungen und Statements der S3-Leitlinie zur komplementären Medizin für Patient*innen mit onkologischen Erkrankungen – Teil 2

et al. 2021

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Tilted Fiber Bragg Grating Active Heater for Controlled and Localised Hyperthermia

Alqarni¹

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We present data from localized heat inducement studies at both cellular and tissue levels along with a computational model built to predict the temperature increase and damage extent in tissues receiving hyperthermia treatment by a fiber-based active heater. This novel fiber-based active heater serves as a heat source and a temperature sensor. Five important insights are highlighted from this thesis work.First, heat-induced controlled cell deaths were observed experimentally in the three cell lines with MCF-10A being more susceptible to heat compared to HEK 293 and MCF7 cells. Second, comparison between the phantom tissue and ex vivo experimental and computational results shows a lesion size of 5×12 mm and 4.87×11.6 mm in the phantom tissue and 7×15 mm and 8.8×14.3 mm in the ex vivo studies at pumping power of 1.8 W for 10 minutes respectively. Thus, this computational model is able to provide information about the heat transfer characteristics caused by the active heater in living biological tissue.

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Conventional cancer treatment alone or with regional hyperthermia for pain relief in lung cancer: A case–control study

Cited by 6 publications

References 26 publications

Systematic review about complementary medical hyperthermia in oncology

Systematic review about complementary medical hyperthermia in oncology

Zentrale Empfehlungen und Statements der S3-Leitlinie zur komplementären Medizin für Patient*innen mit onkologischen Erkrankungen – Teil 2

Tilted Fiber Bragg Grating Active Heater for Controlled and Localised Hyperthermia

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