Conventional Coronary Artery Disease Risk Factors and Coronary Artery Calcium Detected by Electron Beam Tomography in 30,908 Healthy Individuals

Hoff, J.; Daviglus, Martha L.; Chomka, Eva V.; Krainik, Andrew J.; Sevrukov, Alexander; Kondos, George T.

doi:10.1016/s1047-2797(02)00277-6

Cited by 101 publications

(76 citation statements)

References 33 publications

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“…For each model, the reference group consisted of negative scores (CACϭ0); this approach has been used previously. 18 In the full multivariate model (adjusted for age, hypertension, smoking status, diabetes, dyslipidemia, obesity, and physical activity), statistical differences were calculated between the associations of premature FH of CHD in sibling versus parent with any CAC as well as advanced CAC by means of an adjusted Wald test. The association of FH of premature CHD with CAC did not differ substantially in the age-adjusted models and the ageϩCHD risk factors, including BMI-adjusted models; as a result, we have described the analyses on the basis of the full multivariate adjustments only.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, CHD risk factors were self-reported. Hoff et al 18 has shown a good reliability of self-reported histories of CHD risk factors in self-referred individuals for EBT scanning. However, because the CHD risk factors were self-reported, the potential "residual confounding" cannot be ruled out.…”

Section: Limitationsmentioning

confidence: 98%

“…A recent study has demonstrated that a FH of premature CHD in first-degree relatives was independently associated with the presence of CAC in both men and women. 18 In addition, Wang et al 8 have also established a strong association of specifically the presence FH of premature CHD in parents with carotid IMT thickness. The results of the present study confirm the association of a FH of premature CHD with subclinical atherosclerosis and extend the findings of previous studies by describing in detail the association of a sibling history of premature CHD with CAC.…”

Section: Sibling Versus Parental Family History Of Premature Chdmentioning

confidence: 99%

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Coronary Artery Calcification and Family History of Premature Coronary Heart Disease

et al. 2004

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Background-The objective of the study was to assess the association of a family history (FH) of premature coronary heart disease (CHD) with coronary artery calcification (CAC) in asymptomatic individuals and to compare the effects of sibling or parental FH on the risk of subclinical atherosclerosis. Methods and Results-CAC by electron beam tomography was performed in 8549 asymptomatic individuals (69% men; mean age, 52Ϯ9 years). The prevalence and odds of any CAC and extent of CAC stratified according to FH of premature CHD were determined. Those with (1) no FH of CHD, (2) FH of premature CHD in parents, or (3) FH in siblings had a prevalence of CAC of 55%, 64%, and 78% (PϽ0.0001) among men and 27%, 36%, and 56% (PϽ0.0001) among women, respectively. The multivariate regression analysis demonstrated that the odds ratio (95% confidence interval) for the presence of CAC was 1.3 (1.1 to 1.6) among those with positive FH of premature CHD in parents only, 2.3 (1.7 to 3.1) and 2.5 (1.8 to 3.3) among those in siblings and a combined FH compared with those without FH of CHD in men, respectively. Among women, the corresponding odds ratios were 1.3 (1.0 to 1.8), 2.3 (1.7 to 3.6), and 1.9 (1.3 to 3.1), respectively. A similar trend was observed in the association of FH of premature CHD with increasing CAC scores. Conclusions-Our study demonstrates a highly significant association between FH of premature CHD and the presence and extent of CAC. Furthermore, within the limits of self-reporting of family history, our findings suggest that a sibling history is more strongly associated with subclinical coronary atherosclerosis than a parental history of premature CHD.

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Section: Discussionmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 98%

Section: Sibling Versus Parental Family History Of Premature Chdmentioning

confidence: 99%

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Coronary Artery Calcification and Family History of Premature Coronary Heart Disease

et al. 2004

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“…In a study of 30,908 asymptomatic individuals aged 30 to 90 years, conventional clinical risk factors were significantly associated with the presence of detectable coronary calcium 29 . The mean calcium score increased in proportion to the number of CAD risk factors.…”

Section: Ct Calcium Scoringmentioning

confidence: 99%

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Schoenhagen¹,

Tuzcu²

2008

Arq. Bras. Cardiol.

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SummaryCAD remains a major global cause of morbidity and mortality. Comprehensive drug development programs of novel pharmacological treatment strategies frequently utilize traditional mortality/morbidity endpoints studies and additional surrogate endpoints trials. This parallel approach allows an assessment of efficacy several years in advance of the availability of data from clinical endpoint trials. Several atherosclerosis imaging markers have been introduced into these drug-development strategies, including angiography, carotid ultrasound, IVUS, MRI, and CT. This review will discuss the current status of atherosclerosis imaging as an endpoint in progression/regression trials, with an emphasis on evidence-based data. In addition to a discussion of the results of individual imaging modalities, the emerging data comparing different modalities and approaches are presented.

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“…Diabetes is a frequent and strong risk factor for CAC [3,11,12] and individuals with diabetes consistently have higher levels of CAC than do those without diabetes [3,[11][12][13][14]. However, the association between CAC and clinical CVD has not been well studied and appears less consistent in subjects with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Coronary artery and abdominal aortic calcification are associated with cardiovascular disease in type 2 diabetes

2005

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Aims/hypothesis: The goals of this study were to determine whether coronary calcium is associated with the presence of clinical cardiovascular disease in individuals with type 2 diabetes and if the measurement of abdominal aortic calcium may have an independent or added benefit as a surrogate marker for clinical vascular disease. Methods: A cross-sectional study of subjects with type 2 diabetes enrolled in seven medical centres in the USA participating in a Veterans Affairs Cooperative Study of glycaemic control. Enrolled subjects included 309 veterans over 40 years of age with type 2 diabetes, with or without stable cardiovascular disease, who had inadequate glycaemic control (HbA 1 c>7.5%) on oral agents and/or insulin. The study assessed lifestyle behaviours, standard cardiovascular risk factors and coronary artery and abdominal aorta calcification by electron beam computed tomography. Results: Subjects with coronary artery or abdominal aorta calcification present had a strikingly higher prevalence of peripheral artery disease, coronary artery disease and all combined cardiovascular disease. Prevalence of each condition increased from 5-to 13-fold with increasing quintiles of coronary artery calcification and from 2-to 3-fold with increasing abdominal aorta calcification. These associations persisted after adjustment for lifestyle behaviours and standard cardiovascular risk factors. Conclusions/ interpretation: These results support the notion that vascular calcium in type 2 diabetes provides additional information beyond that of standard risk factors in identifying the presence of cardiovascular disease. Subclinical measures of atherosclerosis such as arterial calcification may help more precisely stratify these individuals and alert healthcare providers to those individuals who have particularly accelerated atherosclerosis.

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Conventional Coronary Artery Disease Risk Factors and Coronary Artery Calcium Detected by Electron Beam Tomography in 30,908 Healthy Individuals

Cited by 101 publications

References 33 publications

Coronary Artery Calcification and Family History of Premature Coronary Heart Disease

Coronary Artery Calcification and Family History of Premature Coronary Heart Disease

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Coronary artery and abdominal aortic calcification are associated with cardiovascular disease in type 2 diabetes

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