Conventional disease-modifying anti-rheumatic drugs combined with Chinese Herbal Medicines for rheumatoid arthritis: A systematic review and meta-analysis

Han, Ruijuan; Ren, Hong; Sitong, Zhou; Gu, Sherman; Gu, Yue-Yu; Chen, Meng-Hua

doi:10.1016/j.jtcme.2022.01.005

Cited by 12 publications

(16 citation statements)

References 32 publications

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“…21 Other traditional Chinese herbal medicines used in RA treatment are ngelicae Sinensis Radix, Paeoniae Radix Alba, Cinnamomi Ramulus, Glycyrrhizae Radix et Rhizoma, and Clematidis Radix et Rhizoma, which shows improved treatment efficiency when given with DMARDs. 22 There is very little information available on pharmacodynamics and pharmacokinetic potential of herbal drugs and the incidence of adverse effects like herb-drug and herb-herb interactions. 23 On oral administration, these herbs may show drug-herb or herb-herb interactions which results in various side effects and may create a potential risk to the patient.…”

Section: Herbal Medicine Approachmentioning

confidence: 99%

Lipid Nano-System Based Topical Drug Delivery for Management of Rheumatoid Arthritis: An Overview

Dhule,

Nandgude

2023

Adv Pharm Bull

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The overall purpose of Rheumatoid Arthritis (RA) treatment is to give symptomatic alleviation; there is no recognized cure for RA. Frequent use of potent drugs like Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Disease-modifying antirheumatic drugs, lead to various adverse effects and patient compliance suffers. On the other hand, there are many drawbacks associated with traditional methods, such as high first pass, high clearance rate, and low bioavailability. Drug administration through the skin can be a promising alternative to cope with these drawbacks, increasing patient compliance and providing site-specific action. The stratum corneum, the uppermost non-viable epidermal layer, is one of the primary limiting barriers to skin penetration. Various nanocarrier technologies come into play as drug vehicles to help overcome these barriers. The nanocarrier systems are biocompatible, stable, and have a lower cytotoxic impact. The review discusses several lipid-based nanocarrier systems for anti-rheumatic medicines for topical administration it also discusses in-vivo animal models for Rheumatoid arthritis and provides information on patents granted.

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Section: Herbal Medicine Approachmentioning

confidence: 99%

Lipid Nano-System Based Topical Drug Delivery for Management of Rheumatoid Arthritis: An Overview

Dhule,

Nandgude

2023

Adv Pharm Bull

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“…Die Ergebnisse dieser Studie deuten darauf hin, dass die Kombination von chinesischer Phytotherapie mit csDMARDs die Gesamtwirksamkeit von csDMARDs erhöht und die Häufigkeit von Nebenwirkungen im Vergleich zur Therapie mit csDMARDs verringert. Die Ergebnisse sollten mit Vorsicht interpretiert werden, da methodische Mängel und eine große Heterogenität bei einigen Ergebnissen bestanden und somit die Aussagekraft insgesamt schwächen 31 .…”

Section: Die Chinesische Phytotherapieunclassified

“…Die berichteten Vorteile sollten in weiteren hochwertigen randomisierten kontrollierten Studien überprüft werden. [31].…”

Section: Akupunkturunclassified

Traditionelle chinesische Medizin – Relevant für die Behandlung der rheumatoiden Arthritis?

Frohne,

Keyßer,

Pfeil

2023

Aktuelle Rheumatologie

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ZusammenfassungDie Traditionelle Chinesische Medizin (TCM) hat eine lange Tradition und basiert auf einem eigenen Medizinsystem, welches die physiologischen Abläufe im Körper und die Entstehung von Krankheiten beschreibt. Einige Studien deuten darauf hin, dass die TCM bei entzündlich-rheumatischen Erkrankungen (insbesondere der rheumatoiden Arthritis, RA) wirksam sein könnte. Hauptanwendungsmethoden der TCM bei einer RA stellen die Akupunktur als auch chinesische Heilkräuter dar. Durch die Anwendung der TCM könnte die Wirkung der Disease-modifying Antirheumatic Drugs und Symptomlinderung verbessert als auch die Nebenwirkungsrate reduziert werden. Limitierend für die TCM ist, dass eine systematische wissenschaftliche Evaluation der TCM bisher jedoch fehlt.

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“…[32][33][34][35] Recently, a number of statistical evidence and real world data have been accumulated to support the potential usefulness of IM for inflammatory and immunological improvement in patients with RA. [21,[36][37][38][39][40] For example, in a population-based cohort study in 2020, it was observed that the application of IM could lower the risk of coronary artery disease in RA. Additionally, in a more recent meta-analysis, it was reported that IM could attenuate the adverse effects of DMARDs.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, in a more recent meta-analysis, it was reported that IM could attenuate the adverse effects of DMARDs. [36,39] Considering these circumstances, IM is expected to be worth investigating as a new treatment strategy that can lead to improved treatment results for RA.…”

Section: Introductionmentioning

confidence: 99%

Integrative medicine using East Asian herbal medicine for inflammatory pain in patients with rheumatoid arthritis: A protocol for systematic review and meta-analysis integrated with multiple data mining for core candidate discovery

Jo¹,

Seo²,

Baek³

et al. 2023

Medicine

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Background: Rheumatoid arthritis is a chronic inflammatory autoimmune disease characterized by a wide range of clinical symptoms affecting various bodily functions, including skeletal, vascular, metabolic, and cognitive functions. This review aimed to evaluate the efficacy and safety of integrative medicine (East Asian herbal medicine combined with conventional medicine) used for the treatment of inflammatory pain in rheumatoid arthritis and to identify key candidate drugs based on the data. Methods: A comprehensive literature search will be conducted in 4 core databases (PubMed, Excerpta Medica database, Cochrane Library, and Cumulative Index to Nursing & Allied Health Literature) 4 Korean databases (Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, Research Information Service System, and Korea Citation Index), 2 Chinese databases (Chinese National Knowledge Infrastructure Database and Wanfang data), and 1 Japanese database (Citation Information by National Institute of Informatics) for randomized controlled trials from December 13, 2022. Statistical analysis will be performed using R version 4.1.2 and R Studio program. The American College of Rheumatology 20/50/70 score and rate of adverse events will be the primary outcomes. All outcomes will be analyzed using a random-effects model to produce more statistically conservative results. Sensitivity, meta-regression, and subgroup analyses will be used to identify the sources of any heterogeneity in the study. The revised tool for assessing the risk of bias in randomized trials, version 2.0, will be used to evaluate methodological quality. The overall quality of evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation Pro Framework. Ethics and dissemination: There are no ethical issues, as no primary data will be collected directly from the participants. The results of this review will be reported in a peer-reviewed scientific journal. Trial registration: PROSPERO registration number: CRD42023412385.

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Conventional disease-modifying anti-rheumatic drugs combined with Chinese Herbal Medicines for rheumatoid arthritis: A systematic review and meta-analysis

Cited by 12 publications

References 32 publications

Lipid Nano-System Based Topical Drug Delivery for Management of Rheumatoid Arthritis: An Overview

Lipid Nano-System Based Topical Drug Delivery for Management of Rheumatoid Arthritis: An Overview

Traditionelle chinesische Medizin – Relevant für die Behandlung der rheumatoiden Arthritis?

Integrative medicine using East Asian herbal medicine for inflammatory pain in patients with rheumatoid arthritis: A protocol for systematic review and meta-analysis integrated with multiple data mining for core candidate discovery

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