Conventional high resolution versus fast T2-weighted MR imaging of the heart: assessment of reperfusion induced myocardial injury in an animal model

Miller, Stephan; Schick, Fritz; Scheule, Albertus M.; Vogel, U.; Hiller, Renate; Strotmann, C.; Nägele, Thomas; Hahn, Ulrich; Claussen, Claus D.

doi:10.1016/s0730-725x(00)00213-7

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…For the first time, in HCM patients, we also performed T2 weighted sequences for the detection of an abnormal signal consistent for edema [39][40][41][42] on all our study population. We found 24 (54%) patients showed increased signal intensity.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular magnetic resonance signs of ischemia in hypertrophic cardiomyopathy

Melacini

Corbetti

Calore

et al. 2008

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Cardiovascular magnetic resonance signs of ischemia in hypertrophic cardiomyopathy

Melacini

Corbetti

Calore

et al. 2008

International Journal of Cardiology

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“…The myocardial damage was graded as follows: Grade III, severe injury to the myocardium characterized by severe edema and predominant contraction bands; grade II, moderate injury to the myocardium characterized by regular presence of contraction bands and significant interstitial and cellular edema; grade I, minor injury to the myocardium characterized by hydropic cardiomyocytes, few contractions, and low grade interstitial edema; and grade 0, myocytes appear normal without hydrops, cell disruption or interstitial edema. Myocardial damage was measured using the semi-quantitative scale reported by Miller et al (24).…”

Section: Methodsmentioning

confidence: 99%

Lycium barbarum polysaccharide exhibits cardioprotection in an experimental model of ischemia-reperfusion damage

Hou

Wang

Zhang

2017

Molecular Medicine Reports

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Cardiovascular diseases are a major cause of mortality and disability worldwide. The present study investigated the cardio-protective effects of polysaccharides extracted from Lycium barbarum (LB), the fruit of which is traditionally used in Chinese medicine. Polysaccharides were characterized using Fourier transform infrared spectroscopy and high‑performance liquid chromatography techniques. The present study demonstrated that LB polysaccharides are composed of glucose and fructose monosaccharides in a molar ratio of 1:2. A total of 36 rats were divided into three groups plus a control group, with nine animals in each group, and were used for studying the cardioprotective effects of LB polysaccharides. The low‑dose group received 150 mg/kg body weight (BW) polysaccharides and the high‑dose group received 300 mg/kg BW polysaccharides. The results demonstrated that the LB polysaccharides reduced the levels of myocardial lactate dehydrogenase and increased the sodium‑potassium ATPase and calcium ATPase activities in rats with heart ischemia‑reperfusion injury. In addition, there was a decrease in the myocardial Bax‑positive expression and the rate of myocardial cell apoptosis, along with a dose‑dependent increase in Bcl‑2‑positive expression. Therefore, it was concluded that LB polysaccharides are able to halt the progression of cardiovascular diseases.

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“…Since then, both T2 (66–68) and T1 late enhancement imaging have been utilized to estimate infarct size, T1-weighted largely dominating the scene (36, 39, 69–92). …”

Section: Discussionmentioning

confidence: 99%

Microvascular obstruction after successful fibrinolytic therapy in acute myocardial infarction. Comparison of reteplase vs reteplase+abciximab: A cardiovascular magnetic resonance study

2006

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Background.About one third of patients with TIMI 3 after reperfusion have evidence of microvascular obstruction (MO) which represents an independent predictor of myocardial wall rupture. This explains all efforts made to prevent MO. Magnetic resonance imaging (MRI) has proved to be particularly useful in detecting MO. The aim of this study was to evaluate with MRI if different fibrinolytic regimens in acute myocardial infarction display different effects on left ventricle (LV) volumes and ejection fraction (EF), as well as on myocardial infarct size (MIsz) and MO.Methods.Twenty male patients, mean age 58 years, affected by acute myocardial infarction, ten anterior and ten inferior, were treated with: full dose reteplase in ten, and half dose reteplase plus full dose abciximab (R+Abcx) in the other ten patients. In the fourth day after hospital admission, MRI STIR T2 images were used to quantify MIsz, while 2dflash cineloops were used after the injection of gadolinium, to quantify LV volumes, EF and to detect MO.Results.LV EF was higher in R+Abcx 51±10 than in reteplase 41±8. MIsz was similar in both treatment groups: however a close relationship was present between MIsz and EF in the reteplase group indicating that the greater the MIsz the lower the EF. In R+Abcx this relationship was no longer present, suggesting a protective effect of the drug on microcirculation. In fact extensive MO was present in 25% of all cases, 80% of which in the reteplase group while only 20% in R+Abcx.Conclusion.R+Abcx prevents MO: compared to traditional fibrinolytic therapy it allows better LV function and most likely improved long term survival.

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Conventional high resolution versus fast T2-weighted MR imaging of the heart: assessment of reperfusion induced myocardial injury in an animal model

Cited by 12 publications

References 26 publications

Cardiovascular magnetic resonance signs of ischemia in hypertrophic cardiomyopathy

Cardiovascular magnetic resonance signs of ischemia in hypertrophic cardiomyopathy

Lycium barbarum polysaccharide exhibits cardioprotection in an experimental model of ischemia-reperfusion damage

Microvascular obstruction after successful fibrinolytic therapy in acute myocardial infarction. Comparison of reteplase vs reteplase+abciximab: A cardiovascular magnetic resonance study

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