Conventional <i>versus</i> accelerated corneal collagen cross‐linking in the treatment of keratoconus

Ng, Alex; Chan, Tommy C Y; Cheng, Arthur C.K.

doi:10.1111/ceo.12571

Cited by 91 publications

(80 citation statements)

References 34 publications

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“…; Ng et al. ) declared that no complications arose throughout the follow‐up period. The other studies did not report whether complications occurred or not.…”

Section: Resultsmentioning

confidence: 99%

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Shajari

Kolb

Agha

et al. 2018

Acta Ophthalmologica

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“…; Ng et al. ) declared that no complications arose throughout the follow‐up period. The other studies did not report whether complications occurred or not.…”

Section: Resultsmentioning

confidence: 99%

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Shajari

Kolb

Agha

et al. 2018

Acta Ophthalmologica

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“…While CXL has been proposed as a treatment for other ocular pathologies such as keratitis (Iseli et al, 2008), its main use remains the treatment of keratoconus. In addition to the traditional “Dresden” CXL protocol (Wollensak et al, 2003a), a variety of CXL techniques have emerged, varying from accelerated methods (Ng et al, 2016) to pulsed techniques (Mazzotta et al, 2014) to spatially varying methods for customized therapies (Seiler et al, 2016). However, the current clinical protocol still remains a blanket treatment and does not account for pre-existing biomechanical properties nor the effects of the treatment itself.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model

Han

Singh

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

107

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The biomechanical properties of the cornea play a critical role in forming vision. Diseases such as keratoconus can structurally degenerate the cornea causing a pathological loss in visual acuity. UV-A/riboflavin corneal collagen crosslinking (CXL) is a clinically available treatment to stiffen the cornea and restore its healthy shape and function. However, current CXL techniques do not account for pre-existing biomechanical properties of the cornea nor the effects of the CXL treatment itself. In addition to the inherent corneal structure, the intraocular pressure (IOP) can also dramatically affect the measured biomechanical properties of the cornea. In this work, we present the details and development of a modified Rayleigh-Lamb frequency equation model for quantifying corneal biomechanical properties. After comparison with finite element modeling, the model was utilized to quantify the viscoelasticity of in situ porcine corneas in the whole eye-globe configuration before and after CXL based on noncontact optical coherence elastography measurements. Moreover, the viscoelasticity of the untreated and CXL-treated eyes was quantified at various IOPs. The results showed that the stiffness of the cornea increased after CXL and that corneal stiffness is close to linear as a function of IOP. These results show that the modified Rayleigh-Lamb wave model can provide an accurate assessment of corneal viscoelasticity, which could be used for customized CXL therapies.

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“…16,17 Our previous work also reported a positive correlation between the depth of the demarcation line at the center with the change in the mean keratometry value, implying a greater cross-linking effect with a deeper demarcation line. 18 Using anterior segment optical coherence tomography (AS-OCT), the demarcation line depth can be quantified at the corneal center and at its periphery. 19,20 Conventional CXL has demonstrated a central demarcation line depth of 300 to 350 mm.…”

mentioning

confidence: 99%

Comparison of the Central and Peripheral Corneal Stromal Demarcation Line Depth in Conventional Versus Accelerated Collagen Cross-Linking

Chan

Lai

et al. 2015

Cornea

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Conventional versus accelerated corneal collagen cross‐linking in the treatment of keratoconus

Abstract: Background: This study aims to compare the effect of conventional corneal collagen cross-linking (CXL) with accelerated corneal collagen cross-linking in treatment of keratoconus.

Cited by 91 publications

References 34 publications

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model

Comparison of the Central and Peripheral Corneal Stromal Demarcation Line Depth in Conventional Versus Accelerated Collagen Cross-Linking

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