Conventional Medical Management of Ulcerative Colitis: Sulfasalazine and 5-Aminosalicylates

Khanna, Reena; Marshall, John K.

doi:10.1007/978-1-4614-0998-4_36

Cited by 1 publication

(2 citation statements)

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“…Sulfasalazine is cleaved intraluminally to sulfapyradine and 5‐ASA with the latter being empirically identified as being responsible for improving colitis [Azad Khan et al., ; van Hees et al., ]. Various oral and rectal formulations have been developed that deliver millimolar concentrations of 5‐ASA to the colon [Khanna and Marshall, ]. Once in the colon, bacteria can acetylate 5‐ASA leading to its inactivation [Van Hogezand et al., ].…”

Section: Previously Proposed Mechanisms Of Topical Salicylatesmentioning

confidence: 99%

“…Any remaining 5‐ASA is poorly absorbed into the bloodstream, and its effects are thought to be mostly local in nature [Bondesen et al., ]. In vitro studies have demonstrated a number of effects including both increases and decreases in prostaglandin synthesis, inhibition of NF‐κ B activity, free radical scavenging, inhibition of IL‐1 and TNF‐α, and regulation of immune cell function [Greenfield et al., ; MacDermott, ; Khanna and Marshall, ].…”

Section: Previously Proposed Mechanisms Of Topical Salicylatesmentioning

confidence: 99%

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Salicylates and the Microbiota: A New Mechanistic Understanding of an Ancient Drug's Role in Dermatological and Gastrointestinal Disease

Damman

2013

Drug Development Research

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The proposed mechanism(s) of action of salicylates are as varied as their extraordinary range of clinical indications. Extracted from plant leaves since the beginning of recorded history, salicylates have been used for over 4000 years for the treatment of disease. The anti-inflammatory and antiplatelet agent aspirin (acetylsalicylic acid) was synthesized at the turn of the 20th century and paved the way for salicylates becoming the most widely used drug in the world. Its parent compound salicylic acid as well as the derivatives bismuth subsalicylate and 5-aminosalicylate are invaluable topical treatments for many dermatological and gastrological diseases. Their mode of action is poorly understood, but a developing understanding of the role of the microbiota in diseases of the skin and intestine suggest microbial targets as a possible unifying mechanism. There is a relatively substantial and little-known literature demonstrating the antibiofilm and antibiotic-metabolizing effects of salicylates. A better understanding of this antimicrobial mechanism in dermatological and gastrointestinal diseases could lead to new adjunctive treatments aimed at modulating microbes rather than host inflammation. Drug Dev Res 74 : 344-352, 2013.

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Section: Previously Proposed Mechanisms Of Topical Salicylatesmentioning

confidence: 99%