Conventional renal cell carcinoma with granulomatous reaction: a report of three cases

Hes, Ondřej; Hora, Milan; Vaněček, Tomáš; Šíma, Radek; Šulc, Miroslav; Havlícek, F; Beranova, Milena; Michal, Michal

doi:10.1007/s00428-003-0860-9

Cited by 23 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adipose tissue and other tissues such as, for example, thick blood vessels devoid of elastic layer with the typical arrangement of the myoid stromal cells perpendicularly to the lumina of these vessels, that may be seen in renal angiomyolipoma (PECOMA), were not detected in our cases of RAT. Multinucleated cell granulomas or hyaline globules, which are sometimes seen in conventional clear renal cell carcinomas [8][9][10], were not observed in any of the tumors in our series.…”

Section: Microscopic Findingsmentioning

confidence: 75%

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

et al. 2008

View full text Add to dashboard Cite

We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.

show abstract

Section: Microscopic Findingsmentioning

confidence: 75%

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The authors suggested that his poor prognostic was not influenced by the sarcoid-like reaction but rather the sarcomatoid features. However two other cases reported longer recurrence free survival of 15 [4] and 48 [3] months, respectively. In our case, the sarcoid like reaction was seen peritumoral, without sarcomatoid features, with a recurrence free survival at 30 months follow-up.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma associated with peritumoral sarcoid-like reaction without intratumoral granuloma

2012

View full text Add to dashboard Cite

Non-necrotizing epithelioid granulomas have been described in association with many primary tumors. In such cases, they are designated as sarcoid-like reaction. Although it is more seen in carcinomas than in sarcomas, it is very rarely reported in renal carcinoma. Here, we describe a rare association of prominent peritumoral sarcoid-like reaction without intratumoral granulomas and conventional clear cell renal carcinoma in a 62-year-old-male, without clinical or laboratory finding of sarcoidosis. At 30 months follow-up, he had no recurrence.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4054525336657922

show abstract

“…Tumor-related SLR is postulated to occur due to T cell–mediated reaction against various cancer-associated antigens [7]. Those antigenic factors are believed to be expressed directly by the cancer cells or shed as soluble antigen during tumor destruction.…”

Section: Discussionmentioning

confidence: 99%

“…Only fewer than 15 cases have been reported in the English literature since early 1990s [3,7,8,10-13]. We reviewed the clinical and pathological characteristics of previously reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…However, tumor-related SLR may only be secondary phenomenon due to tumor-shed antigens. In Table 1, there is a case without recurrence or distant metastasis after a long follow-up period (4 years) [7], but this does not support the hypothesis that tumor-related SLR is associated with better prognosis. In the reviewed cases, only one patient died of distant metastases during the follow-up period (6 months) [3].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clear Cell Renal Cell Carcinoma with Intratumoral Granulomatous Reaction: A Case Report and Review of the Literature

Kim

et al. 2017

J Pathol Transl Med

View full text Add to dashboard Cite

Granulomatous reaction associated with clear cell renal cell carcinoma (CCRCC) is a rare finding, and only a few cases have been described in the literature. It is postulated to occur due to cancer-related antigenic factors such as cancer cells themselves or soluble tumor antigens shed into the blood. Herein, we describe a case of a 56-year-old male patient diagnosed with CCRCC with intratumoral granulomatous inflammation.

show abstract

Conventional renal cell carcinoma with granulomatous reaction: a report of three cases

Cited by 23 publications

References 9 publications

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

Renal cell carcinoma associated with peritumoral sarcoid-like reaction without intratumoral granuloma

Clear Cell Renal Cell Carcinoma with Intratumoral Granulomatous Reaction: A Case Report and Review of the Literature

Contact Info

Product

Resources

About