Conventional wisdom: observation, experience, anecdote, and science in breast imaging.

Kopans, Daniel B.

doi:10.2214/ajr.162.2.8310914

Cited by 19 publications

(2 citation statements)

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“…This is, in fact, far from reality. The majority of women in their 30s do, indeed, have dense breast tissue, but the percentage changes gradually and steadily with increasing age with no abrupt change at the age of 50 or at menopause [53,55]. We have confirmed this in a review of more than 150,000 mammographic studies (unpublished data).…”

Section: Data Grouping Can Be Misleadingsupporting

confidence: 61%

Bias in the Medical Journals: A Commentary

Kopans

2005

American Journal of Roentgenology

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Most readers are not aware of the fact that medical journals may have an unspoken bias in the papers that they select for publication. These biases can have far-reaching consequences. The controversy over mammography screening for women ages 40-49 is a case in point. Several medical journals knowingly have refused to provide women with accurate information. Consequently, women have been led to believe that the age of 50 has some real significance with regard to screening when the fact is that it has none.

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Section: Data Grouping Can Be Misleadingsupporting

confidence: 61%

Bias in the Medical Journals: A Commentary

Kopans

2005

American Journal of Roentgenology

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“…Thus a large fraction (well over 50% in most centers) of the suspicious structures identified in mammograms are non-cancerous and further diagnosis-usually by biopsy-is necessary before deciding whether to actually treat the patient for cancer [15,23]. X-ray mammography has the additional drawback that its sensitivity for cancer is significantly decreased in patients with radiographically dense breasts (which can occur because of scarring or in patients under 50 who retain substantial glandular tissue) [9,21,27,28,29,30].…”

Section: Strengths and Limitations Of X-ray Mammographymentioning

confidence: 99%

A compact, discrete CsI(Tl) scintillator/Si photodiode gamma camera for breast cancer imaging

Gruber

2000

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Recent clinical evaluations of scintimammography (radionuclide breast imaging) are promising and suggest that this modality may prove a valuable complement to X-ray mammography and traditional breast cancer detection and diagnosis techniques. Scintimammography, however, typically has difficulty revealing tumors that are less than 1 cm in diameter, are located in the medial part of the breast, or are located in the axillary nodes. These shortcomings may in part be due to the use of large, conventional Anger cameras not optimized for breast imaging. In this thesis I present compact single photon camera technology designed specifically for scintimammography which strives to alleviate some of these limitations by allowing better and closer access to sites of possible breast tumors. Specific applications are outlined. The design is modular, thus a camera of the desired size and geometry can be constructed from an array (or arrays) of individual modules and a parallel hole lead collimator for directional information. Each module consists of: (1) an array of 64 discrete, optically-isolated CsI(Tl) scintillator crystals 3 × 3 × 5 mm 3 in size, (2) an array of 64 low-noise Si PIN photodiodes matched 1-to-1 to the scintillator I could not have completed this work without the help of many people, and I am deeply indebted to all of them. I would like to start by acknowledging the tremendous contributions Bill Moses has made to my graduate school experience. Although he never served as my advisor in an official capacity, Bill guided my Ph.D. work day in and day out and has been a mentor to me in everything from how to debug an integrated circuit to how to remain happy while working through the frustrations inherent in research. Bill has been an exemplary role model both as a researcher and as a person, and it is hard to imagine how I could possibly have completed this degree without his supervision, insight, and friendship. I also owe a great deal of thanks to my advisor, Steve Derenzo, for guiding my graduate research for both my M.S. and Ph.D. projects, as well as for encouraging me to pursue nuclear medicine and medical imaging. Throughout the course of my work he has always proven an invaluable source of expertise and support. The leader of our Center for Functional Imaging family, Tom Budinger, is also very deserving of my thanks, for not only has he has shown a great deal of faith and confidence in me, but he has constantly pushed both my project and my research efforts forward. I also thank the Center for Functional Imaging staff as a whole, for certainly everyone who works there has contributed to my wonderful experience as a graduate student researcher. Bruce Hasegawa not only served on both my qualifying exam committee (as chair, no less) and my thesis committee, he also spearheaded several classes I took and was a constant figure of support and guidance at professional conferences. I still recall visiting with Bruce when I was first considering the joint UC Berkeley-UC San Francisco bioengineering program years ago...

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Strategies for Improving Sensitivity of Screening Mammography for Women Aged 40 to 49 Years

Feig¹

1996

JAMA

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Conventional wisdom: observation, experience, anecdote, and science in breast imaging.

Cited by 19 publications

References 1 publication

Bias in the Medical Journals: A Commentary

Bias in the Medical Journals: A Commentary

A compact, discrete CsI(Tl) scintillator/Si photodiode gamma camera for breast cancer imaging

Strategies for Improving Sensitivity of Screening Mammography for Women Aged 40 to 49 Years

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