Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing

Hosseini, Motaharesadat; Dalley, Andrew J.; Shafiee, Abbas

doi:10.3390/pharmaceutics14122749

Cited by 3 publications

(3 citation statements)

References 170 publications

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“…[ 330 ] This requires the development and integration of advanced fabrication systems to model the full complexity of atherosclerosis. [ 331 , 332 ] A recent study demonstrated the multimodal fabrication principle in atherosclerosis by combining volumetric bioprinting with melt electrowriting to create stenosed vessels with physiologically relevant mechanical properties. [ 316 ] Multimodal approaches will allow tuning of the vessel properties to match the changes in the mechanical properties of the vessel wall and plaque associated with atherosclerosis progression, ultimately improving the utility of tissue‐engineered and biofabricated models.…”

Section: Critical Outlook and Future Directionsmentioning

confidence: 99%

Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries

Vuong,

Bartolf‐Kopp,

Andelovic

et al. 2024

Advanced Science

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Atherosclerosis is the primary cause of cardiovascular disease, resulting in mortality, elevated healthcare costs, diminished productivity, and reduced quality of life for individuals and their communities. This is exacerbated by the limited understanding of its underlying causes and limitations in current therapeutic interventions, highlighting the need for sophisticated models of atherosclerosis. This review critically evaluates the computational and biological models of atherosclerosis, focusing on the study of hemodynamics in atherosclerotic coronary arteries. Computational models account for the geometrical complexities and hemodynamics of the blood vessels and stenoses, but they fail to capture the complex biological processes involved in atherosclerosis. Different in vitro and in vivo biological models can capture aspects of the biological complexity of healthy and stenosed vessels, but rarely mimic the human anatomy and physiological hemodynamics, and require significantly more time, cost, and resources. Therefore, emerging strategies are examined that integrate computational and biological models, and the potential of advances in imaging, biofabrication, and machine learning is explored in developing more effective models of atherosclerosis.

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Section: Critical Outlook and Future Directionsmentioning

confidence: 99%

Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries

Vuong,

Bartolf‐Kopp,

Andelovic

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

“…92 The advancements in scaffold fabrication techniques (e.g., melt electrowriting, and (3D) printing) enabled the development of structures with advanced architectures. 93,94 The electrospinning technique is one of the approaches for scaffold fabrication due to its capacity to resemble the fibrous structure of ECM. Electrospun products have been widely used to develop wound dressing substrates.…”

Section: Reviewmentioning

confidence: 99%

“…, melt electrowriting, and (3D) printing) enabled the development of structures with advanced architectures. 93,94…”

Section: Regenerative Approaches To Indue Skin Innervationmentioning

confidence: 99%