Convergent and divergent mechanisms of peroxisomal and mitochondrial division

Abstract

Organelle division and segregation are important in cellular homeostasis. Peroxisomes (POs) and mitochondria share a core division machinery and mechanism of membrane scission. The division of each organelle is interdependent not only on the other but also on other organelles, reflecting the dynamic communication between subcellular compartments, even as they coordinate the exchange of metabolites and signals. We highlight common and unique mechanisms involved in the fission of these organelles under the premise that much can be gleaned regarding the division of one organelle based on information available for the other.

The peroxisome: an update on mysteries 3.0

“…Remarkably, except for PEX11β, the fission proteins are shared with mitochondria, likely to coordinate peroxisomal and mitochondrial dynamics due to the two organelles’ cooperative functions in fatty acid degradation and ROS homeostasis. Similarities and differences between peroxisomal and mitochondrial division have recently been reviewed (Subramani et al 2023 ). Patients with a loss of DRP1, MFF or PEX11β function have been identified who suffer from neurological abnormalities and exhibit elongated peroxisomes (and mitochondria—in DRP1 and MFF deficiency) due to impaired organelle dynamics (recently reviewed in Carmichael et al 2022 ).…”