2024
DOI: 10.1101/2024.10.10.617607
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Convergent depression of activity-dependent bulk endocytosis in rodent models of autism spectrum disorders

Katherine Bonnycastle,
Peter C. Kind,
Michael A. Cousin

Abstract: The key pathological mechanisms underlying autism spectrum disorders (ASDs) remain relatively undetermined, potentially due to the heterogenous nature of the condition. Targeted studies of a series of monogenic ASDs have revealed postsynaptic dysfunction as a central conserved mechanism. Presynaptic dysfunction is emerging as an additional disease locus in neurodevelopmental disorders, however it is unclear whether this dysfunction drives ASDs or is an adaptation to the altered brain microenvironment. To deter… Show more

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