Convergent evolution of SOCS4 between yak and Tibetan antelope in response to high-altitude stress

Wang, Zefu; Ma, Tao; Ma, Jianchao; jinsoo, Han; Ding, Luming; Qiu, Qiang

doi:10.1016/j.gene.2015.08.024

Cited by 17 publications

(18 citation statements)

References 55 publications

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“…SOCS4 has been reported to participate in HIF-1a regulation and acts as an adaptive mechanism to hypoxia (Kamura et al, 2000). Moreover, SOCS4's convergent evolution among yak and Tibetan antelope was detected by a convergent signature and phylogenetic analysis, which might explain their high-altitude adaptations (Wang et al, 2015). Reptiles are ectotherms distributed across various environments such as marine, fresh-water, mountains, and flatlands (Zimmerman, Vogel & Bowden, 2010).…”

Section: Discussionmentioning

confidence: 99%

Genomic evidence of adaptive evolution in the reptilian SOCS gene family

Xia

Zhang

Sun

et al. 2021

PeerJ

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The suppressor of the cytokine signaling (SOCS) family of proteins play an essential role in inhibiting cytokine receptor signaling by regulating immune signal pathways. Although SOCS gene functions have been examined extensively, no comprehensive study has been performed on this gene family’s molecular evolution in reptiles. In this study, we identified eight canonical SOCS genes using recently-published reptilian genomes. We used phylogenetic analysis to determine that the SOCS genes had highly conserved evolutionary dynamics that we classified into two types. We identified positive SOCS4 selection signals in whole reptile lineages and SOCS2 selection signals in the crocodilian lineage. Selective pressure analyses using the branch model and Z-test revealed that these genes were under different negative selection pressures compared to reptile lineages. We also concluded that the nature of selection pressure varies across different reptile lineages on SOCS3, and the crocodilian lineage has experienced rapid evolution. Our results may provide a theoretical foundation for further analyses of reptilian SOCS genes’ functional and molecular mechanisms, as well as their roles in reptile growth and development.

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Section: Discussionmentioning

confidence: 99%

Genomic evidence of adaptive evolution in the reptilian SOCS gene family

Xia

Zhang

Sun

et al. 2021

PeerJ

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“…Investigations using a SOCS-4 deficient mouse model and a SOCS-4 knockdown cell model demonstrated the important regulatory role of SOCS-4 in the inflammatory response to influenza and parasite infection, as well as a novel function of SOCS-4 in modulating T cell receptor (TCR) signalling 16 , 17 . Moreover, another study hypothesised that SOCS-4 may have a regulatory effect on HIF-1α 18 . Since EGF, STAT-3, STAT-6 and HIF-1α, as well as inflammation, are components involved in the wound healing process, it is feasible that SOCS-4 may also play an important role in regulating wound healing, and this is further highlighted by our previous clinical observations indicating the dysregulation of this molecule between non-healing and healing chronic wounds 19 .…”

Section: Discussionmentioning

confidence: 99%

“…Studies have indicated that SOCS-4 plays regulatory roles in inflammation caused by influenza and parasite infection 16 , 17 . An additional study has provided evidence to suggest that SOCS-4 may hold the potential to regulate hypoxia inducible factor (HIF)−1α, a mediator involved in the adaptation to hypoxia 18 . Since inflammation and hypoxia are involved in wound healing, SOCS-4 may also have a regulatory role within the wound healing process.…”

Section: Introductionmentioning

confidence: 99%

In vitro significance of SOCS-3 and SOCS-4 and potential mechanistic links to wound healing

Feng

Sanders

Morgan

et al. 2017

Sci Rep

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Wound healing and the management of chronic wounds represent a significant burden on the NHS. Members of the suppressor of cytokine signalling (SOCS) family have been implicated in the regulation of a range of cellular processes. The current study aims to explore the importance of SOCS-3 and SOCS-4 in regulating cellular traits associated with wound healing. SOCS-3 over-expression and SOCS-4 knockdown mutant lines were generated and verified using q-PCR and western blotting in human keratinocytes (HaCaT) and endothelial cells (HECV). Over-expression of SOCS-3 resulted in a significantly reduced proliferative rate in HaCaT keratinocytes and also enhanced the tubule formation capacity of HECV cells. SOCS-4 knockdown significantly reduced HaCaT migration and HECV cell tubule formation. Suppression of SOCS-4 influenced the responsiveness of HaCaT and HECV cells to EGF and TGFβ and resulted in a dysregulation of phospho-protein expression in HaCaT cells. SOCS-3 and SOCS-4 appear to play regulatory roles in a number of keratinocyte and endothelial cellular traits associated with the wound healing process and may also be able to regulate the responsiveness of these cells to EGF and TGFβ. This implies a potential regulatory role in the wound healing process and, thus highlights their potential as novel therapies.

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“…These species can adapt well to the alpine grassland environment, but they can also thrive and reproduce under harsh plateau environmental conditions, such as thin air, cold temperatures, and short grass [ 3 ]. Yak is the typical representative animal to learn the adaptability to the highland environment, and its specific physiological mechanisms are stable and heritable after long-term adaption and evolution in this environment [ 4 ]. Also, to study on the physiological mechanisms of yaks under special plateau conditions should be of great significance to learn the influences of the high-altitude environment to the physiological mechanisms [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Toward Understanding the Genetic Basis of Yak Ovary Reproduction: A Characterization and Comparative Analyses of Estrus Ovary Transcriptiome in Yak and Cattle

et al. 2016

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BackgroundYaks (Bos grunniens) are endemic species that can adapt well to thin air, cold temperatures, and high altitude. These species can survive in harsh plateau environments and are major source of animal production for local residents, being an important breed in the Qinghai–Tibet Plateau. However, compared with ordinary cattle that live in the plains, yaks generally have lower fertility. Investigating the basic physiological molecular features of yak ovary and identifying the biological events underlying the differences between the ovaries of yak and plain cattle is necessary to understand the specificity of yak reproduction. Therefore, RNA-seq technology was applied to analyze transcriptome data comparatively between the yak and plain cattle estrous ovaries.ResultsAfter deep sequencing, 3,653,032 clean reads with a total of 4,828,772,880 base pairs were obtained from yak ovary library. Alignment analysis showed that 16992 yak genes mapped to the yak genome, among which, 12,731 and 14,631 genes were assigned to Gene Ontology (GO) categories and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Furthermore, comparison of yak and cattle ovary transcriptome data revealed that 1307 genes were significantly and differentially expressed between the two libraries, wherein 661 genes were upregulated and 646 genes were downregulated in yak ovary. Functional analysis showed that the differentially expressed genes were involved in various Gene Ontology (GO) categories and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. GO annotations indicated that the genes related to “cell adhesion,” “hormonal” biological processes, and “calcium ion binding,” “cation transmembrane transport” molecular events were significantly active. KEGG pathway analysis showed that the “complement and coagulation cascade” pathway was the most enriched in yak ovary transcriptome data, followed by the “cytochrome P450” related and “ECM–receptor interaction” pathways. Moreover, several novel pathways, such as “circadian rhythm,” were significantly enriched despite having no evident associations with the reproductive function.ConclusionOur findings provide a molecular resource for further investigation of the general molecular mechanism of yak ovary and offer new insights to understand comprehensively the specificity of yak reproduction.

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Convergent evolution of SOCS4 between yak and Tibetan antelope in response to high-altitude stress

Cited by 17 publications

References 55 publications

Genomic evidence of adaptive evolution in the reptilian SOCS gene family

Genomic evidence of adaptive evolution in the reptilian SOCS gene family

In vitro significance of SOCS-3 and SOCS-4 and potential mechanistic links to wound healing

Toward Understanding the Genetic Basis of Yak Ovary Reproduction: A Characterization and Comparative Analyses of Estrus Ovary Transcriptiome in Yak and Cattle

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