One of the largest mass movements of displaced people from their homelands in recent history must be recognized and assisted by the Free World. The unprovoked Russian attacks on Ukraine beginning in February 2022 will leave long-lasting devastating effects on millions of innocent victims. Nations worldwide, especially NATO member countries, will need to intervene to ameliorate the situation. This letter describes major public health issues apart from the coronavirus disease 2019 (COVID-19) pandemic that are emerging concerns, such as shortages of health-care professionals, chronic care treatments and health prevention services, disinformation communication campaigns affecting the health-care infrastructure, and the generational impact of the conflict on people’s mental health. A global response and public health support need immediate action, including humanitarian assistance, food security, clean water supplies, adequate shelter, and safe transportation out of the active military zones.