2011
DOI: 10.1089/dia.2010.0124
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Conversion from Intravenous Insulin to Subcutaneous Insulin After Cardiovascular Surgery: Transition to Target Study

Abstract: No subcutaneous insulin regimen implemented approximately 1 day after cardiac surgery showed significantly better control of blood glucose over the 3-day study period. Further studies are needed to determine optimal formulae for effecting an early transition to subcutaneous insulin after cardiac surgery or whether it is preferable and/or necessary to continue intravenous insulin therapy for an additional period of time.

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Cited by 28 publications
(27 citation statements)
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“…A relevant goal of this transition phase is to accurately determine a daily dose requirement that can be administered as basal/prandial/correctional or basalcorrectional insulin therapy depending upon the patient oral intake status. Similar to previously published recommendations [76][77][78] we suggest using 60-80% of the total daily calculated insulin requirement based on the final 6 h of the infusion rate. Other institutions have attained modest and safe control using a transition from IV to SQ insulin of 50% of the daily calculated dose [79].…”
Section: Management Of Hyperglycemia and Insulin Use In The Hospitalsupporting
confidence: 64%
“…A relevant goal of this transition phase is to accurately determine a daily dose requirement that can be administered as basal/prandial/correctional or basalcorrectional insulin therapy depending upon the patient oral intake status. Similar to previously published recommendations [76][77][78] we suggest using 60-80% of the total daily calculated insulin requirement based on the final 6 h of the infusion rate. Other institutions have attained modest and safe control using a transition from IV to SQ insulin of 50% of the daily calculated dose [79].…”
Section: Management Of Hyperglycemia and Insulin Use In The Hospitalsupporting
confidence: 64%
“…In the ICU, intravenous infusion is the preferred route of insulin administration. When the patient is transitioned off intravenous insulin to subcutaneous therapy, precautions should be taken to prevent hyperglycemia escape (564,565). Outside of critical care units, scheduled subcutaneous insulin that delivers basal, nutritional, and correctional (supplemental) components is recommended.…”
Section: Antihyperglycemic Agents In Hospitalized Patientsmentioning
confidence: 99%
“…A patient with type 1 or type 2 diabetes being transitioned to outpatient subcutaneous insulin should receive subcutaneous basal insulin 2-4 h before the intravenous insulin is discontinued. Converting to basal insulin at 60-80% of the daily infusion dose has been shown to be effective (2,35,36). For patients continuing regimens with concentrated insulin in the inpatient setting, it is important to ensure the correct dosing by utilizing an individual pen and cartridge for each patient, meticulous pharmacist supervision of the dose administered, or other means (37,38).…”
Section: Transitioning Intravenous To Subcutaneous Insulinmentioning
confidence: 99%