1998
DOI: 10.1016/s0041-1345(98)00229-2
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Conversion From Neoral (Cyclosporine) to Tacrolimus of Kidney Transplant Recipients for Gingival Hyperplasia or Hypertrichosis

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Cited by 41 publications
(23 citation statements)
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“…The dosage of CyA, duration of therapy as well as plasmatic and salivary concentrations of CyA play a central role. In addition, many other factors such as standards of oral hygiene, age, genetic predisposition, gingival infl ammation, some growth factors, especially TGF β and synergic or protective eff ects of other prescribed drugs contribute to the development of gingival hyperplasia 7,28 . Gingival hyperplasia and hypertrichosis usually regressed completely within several months after switch from CyA to tacrolimus in the majority of patients effected.…”
Section: Discussionmentioning
confidence: 99%
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“…The dosage of CyA, duration of therapy as well as plasmatic and salivary concentrations of CyA play a central role. In addition, many other factors such as standards of oral hygiene, age, genetic predisposition, gingival infl ammation, some growth factors, especially TGF β and synergic or protective eff ects of other prescribed drugs contribute to the development of gingival hyperplasia 7,28 . Gingival hyperplasia and hypertrichosis usually regressed completely within several months after switch from CyA to tacrolimus in the majority of patients effected.…”
Section: Discussionmentioning
confidence: 99%
“…Gingival hyperplasia and hypertrichosis usually regressed completely within several months after switch from CyA to tacrolimus in the majority of patients effected. Residual gingival hyperplasia may persist in some individuals but is generally asymptomatic and requires no further specifi c dental treatment 7 . In our study gingival hyperplasia and hypertrichosis signifi cantly or completely resolved in all patients converted to tacrolimus.…”
Section: Discussionmentioning
confidence: 99%
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“…Çocuk ve adolesanlar orta ve şiddetli hipertrikoz için en fazla riske sahiptir. Hipertrikoz ilaç kesildikten sonra 1-2 ay içinde geriler (3,28).…”
Section: İlaçla İlişkili Edinsel Generalizeunclassified
“…Discontinuing cyclosporine leads to resolution of excess hair in 1 to 2 months. 4,[8][9][10][11] Alternatives to cyclosporine including tacrolimus and sirolimus have lower rates of hypertrichosis. 12 Excess hair can be removed by various methods.…”
mentioning
confidence: 99%