2004
DOI: 10.1016/j.transproceed.2004.05.039
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Conversion from tacrolimus to cyclosporine for a non–dose-dependent tacrolimus-induced toxicity, a pediatric kidney transplant recipient case report

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Cited by 4 publications
(2 citation statements)
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“…222,345,346 Arterioles appear to be the principal target. 347,348 Infarction Wedge-shaped renal cortical infarcts are occasionally found in aged rodents, usually associated with chronic renal disease of sufficient severity to compromise blood flow. Later changes include hyalinization of the media.…”
Section: Vascular Changesmentioning
confidence: 99%
“…222,345,346 Arterioles appear to be the principal target. 347,348 Infarction Wedge-shaped renal cortical infarcts are occasionally found in aged rodents, usually associated with chronic renal disease of sufficient severity to compromise blood flow. Later changes include hyalinization of the media.…”
Section: Vascular Changesmentioning
confidence: 99%
“…However, tacrolimus has several serious side effects, including renal toxicity, neurotoxicity, diabetes, and hypertension. In clinical applications, tacrolimus often exhibits toxicity or rejection within the specified treatment concentration range for the following reasons: it covers a narrow therapeutic window, its pharmacokinetics and pharmacodynamics differ among individuals, and it lacks a close correlation between dosage and serum concentration; as a result, clinical treatment becomes difficult (Henry, 1999;Sperschneider et al, 2001;Margreiter et al, 2002;Ghio et al, 2004). For the most efficient immunosuppressant treatment and to reduce adverse reactions, patients who take tacrolimus after receiving organ transplants should have routine therapeutic drug monitoring.…”
Section: Introductionmentioning
confidence: 99%