Conversion of cardiac and liver transplant recipients from HPLC and FPIA (polyclonal) to an FPIA (monoclonal) technique for measurement of blood cyclosporin A

McBride, James H.; Kim, Steaven; Rodgerson, Denis O.; Reyes, Aaron

doi:10.1002/(sici)1098-2825(1998)12:6<337::aid-jcla2>3.0.co;2-d

Cited by 5 publications

(2 citation statements)

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“…9 The FPIA technique was compared with liquid chromatography to evaluate cyclosporine A and also showed good correlation of the results. 10 Similarly, the CEDIA and FPIA methods were purported to be well correlated during the validation process performed by our laboratory (slope = 1.02 intercept near 0 µg/L) (G. S. Retzinger, personal communication, February 2008). Despite this, our observation was significant variability between the 2 assays both within and between patients.…”

Section: Discussionmentioning

confidence: 93%

The Impact of a Change in Tacrolimus Monitoring Immunoassay Techniques on Clinical Decision Making

et al. 2010

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Section: Discussionmentioning

confidence: 93%

The Impact of a Change in Tacrolimus Monitoring Immunoassay Techniques on Clinical Decision Making

et al. 2010

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“…For CsA level monitoring whole blood rather than plasma should be used, and factors which affect the activity of the mixed function oxidase system cytochrome P-450 must be considered, ie liver dysfunction and many drugs. 23,24 Administration of MTX Dosage: It is commonly agreed that MTX should be administered at a dose of 10 mg/m 2 . Also, most centres support the idea that, in cases where a paediatric patient is only at low risk of developing GVHD, he/she should either receive no MTX at all or just a very limited dose (ie on days +1, +3 and +6 after BMT).…”

Section: Administration Of Csamentioning

confidence: 99%

Statement of current majority practices in graft-versus-host disease prophylaxis and treatment in children

Peters

Minkov

Gadner

et al. 2000

Bone Marrow Transplant

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Summary:Great variations exist in the prophylaxis and treatment of GVHD in children undergoing allogeneic stem cell transplantation (SCT). The EBMT Working Party Paediatric Diseases (EBMT-WP PD) and the International BFM Study Group -Subcommittee Bone Marrow Transplantation (IBFM-SG), aimed at evaluating current local standards in the prevention and treatment of GVHD and steps which can be taken to achieve a uniform policy for the individual methods. Several conferences with their members assessed practices which are mainly applied or under investigation in children and identified where additional information is needed. For prevention of GVHD, the majority of the paediatric centres prefer CsA ± MTX. Addition of folinic acid to MTX was considered for reduction of side-effects. During treatment of acute GVHD most centres administer prednisolone and whole blood level-adjusted CsA as medications of first choice. In cases of poor or no response to this therapy, additional immunosuppressive agents such as ATG, mycophenolate-mofetile and tacrolimus are being increasingly used. The treatment of chronic GVHD usually consists of various combinations of prednisolone and CsA. In severe cases, extracorporeal photopheresis, psoralene-UVA (PUVA) and thalidomide are administered. Bone Marrow Transplantation (2000) 26, 405-411. Keywords: graft-versus-host disease; prophylaxis; therapy; children; allogeneic bone marrow transplantation Graft-versus-host disease (GVHD) is still a major complication after allogeneic stem cell transplantation (SCT) and has a remarkable influence on the outcome of this procedure.Although younger subjects tend to develop GVHD less The most effective approaches to prevent GVHD are lymphocyte depletion to remove effector cells from the graft, and separation of T cells from other accessory cells. However, these methods may result in increased engraftment failure and a weaker graft-versus-leukaemia (GVL) effect. 4 Thus, many paediatric SCT centres prefer GVHD prophylaxis by pharmacological means, using single or multiple immunosuppressive drugs. 5 In patients with malignant diseases, a major goal of allogeneic SCT is the immunologic GVL effect. 6 To maximise this reaction, it has been attempted to adapt GVHD prophylaxis to the needs of individual patients. 7,8 Therefore, it is not surprising that many groups have developed individual protocols for the prevention and therapy of GVHD which renders an interpretation of pooled patient data difficult. [9][10][11] Response to primary GVHD therapy is one of the most important predictors of long-term survival. 12 Furthermore, in young children the impact of optimal GVHD therapy is important because the growing organism is vulnerable to the consequences of GVHD itself. 13,14 So far only very few studies have been able to provide information about the efficacy of various therapeutic modalities used for the treatment of acute and chronic GVHD in childhood. [15][16][17][18] Therefore, the members of the EBMT Working Party pediatric diseases (WP-PD) and of the Internat...

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Methods of Analysis of Drugs and Drug Metabolites

Markey

2012

Principles of Clinical Pharmacology

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Conversion of cardiac and liver transplant recipients from HPLC and FPIA (polyclonal) to an FPIA (monoclonal) technique for measurement of blood cyclosporin A

Cited by 5 publications

References 15 publications

The Impact of a Change in Tacrolimus Monitoring Immunoassay Techniques on Clinical Decision Making

The Impact of a Change in Tacrolimus Monitoring Immunoassay Techniques on Clinical Decision Making

Statement of current majority practices in graft-versus-host disease prophylaxis and treatment in children

Methods of Analysis of Drugs and Drug Metabolites

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