Conversion of lignocellulose to biofuels and chemicals via sugar platform: An updated review on chemistry and mechanisms of acid hydrolysis of lignocellulose

Zhou, Ziyuan; Liu, Dehua; Zhao, Xuebing

doi:10.1016/j.rser.2021.111169

Cited by 201 publications

(68 citation statements)

References 263 publications

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“…10 ) were proposed. In the initial stage of PHP pretreatment, lignocellulose was penetrated by the concentrated H 3 PO 4 , while hemicellulose underwent acid-catalyzed hydrolysis and dehydration due to its branched and amorphous chemical structure [ 47 ]. The acetyl groups on the branches of hemicellulose structure released and formed acetic acid.…”

Section: Resultsmentioning

confidence: 99%

Self-generated peroxyacetic acid in phosphoric acid plus hydrogen peroxide pretreatment mediated lignocellulose deconstruction and delignification

Tian

Chen

Shen

et al. 2021

Biotechnol Biofuels

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Background Peroxyacetic acid involved chemical pretreatment is effective in lignocellulose deconstruction and oxidation. However, these peroxyacetic acid are usually artificially added. Our previous work has shown that the newly developed PHP pretreatment (phosphoric acid plus hydrogen peroxide) is promising in lignocellulose biomass fractionation through an aggressive oxidation process, while the information about the synergistic effect between H3PO4 and H2O2 is quite lack, especially whether some strong oxidant intermediates is existed. In this work, we reported the PHP pretreatment system could self-generate peroxyacetic acid oxidant, which mediated the overall lignocellulose deconstruction, and hemicellulose/lignin degradation. Results The PHP pretreatment profile on wheat straw and corn stalk were investigated. The pathways/mechanisms of peroxyacetic acid mediated-PHP pretreatment were elucidated through tracing the structural changes of each component. Results showed that hemicellulose was almost completely solubilized and removed, corresponding to about 87.0% cellulose recovery with high digestibility. Rather high degrees of delignification of 83.5% and 90.0% were achieved for wheat straw and corn stalk, respectively, with the aid of peroxyacetic acid oxidation. A clearly positive correlation was found between the concentration of peroxyacetic acid and the extent of lignocellulose deconstruction. Peroxyacetic acid was mainly self-generated through H2O2 oxidation of acetic acid that was produced from hemicellulose deacetylation and lignin degradation. The self-generated peroxyacetic acid then further contributed to lignocellulose deconstruction and delignification. Conclusions The synergistic effect of H3PO4 and H2O2 in the PHP solvent system could efficiently deconstruct wheat straw and corn stalk lignocellulose through an oxidation-mediated process. The main function of H3PO4 was to deconstruct biomass recalcitrance and degrade hemicellulose through acid hydrolysis, while the function of H2O2 was to facilitate the formation of peroxyacetic acid. Peroxyacetic acid with stronger oxidation ability was generated through the reaction between H2O2 and acetic acid, which was released from xylan and lignin oxidation/degradation. This work elucidated the generation and function of peroxyacetic acid in the PHP pretreatment system, and also provide useful information to tailor peroxide-involved pretreatment routes, especially at acidic conditions. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Self-generated peroxyacetic acid in phosphoric acid plus hydrogen peroxide pretreatment mediated lignocellulose deconstruction and delignification

Tian

Chen

Shen

et al. 2021

Biotechnol Biofuels

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“…Pretreatment is a pre-requisite step to facilitate the release of fermentable sugars either by chemical or enzymatic hydrolysis. Dilute acid pretreatment has been considered as one of the most promising approaches with potential commercial applications because the process employs cheap mineral acids such as sulfuric acid and can hydrolyze most of hemicelluloses to fermentable sugars [ 44 ]. However, stress factors including organic acids, furan aldehydes, and phenols are formed inevitably [ 45 ] (Fig.…”

Section: Response Of S Cerevisiae To Stress Factorsmentioning

confidence: 99%

“…Lignocellulosic biomass is primarily composed of cellulose (25–55%), hemicellulose (8–50%) and lignin (10–35%) depending on the plant species [ 18 ]. Various fuels and chemicals can be produced by thermal, thermochemical and biological conversion of lignocellulosic biomass.…”

Section: Introductionmentioning

confidence: 99%

Response mechanisms of Saccharomyces cerevisiae to the stress factors present in lignocellulose hydrolysate and strategies for constructing robust strains

Liu

Zhao

2022

Biotechnol Biofuels

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Bioconversion of lignocellulosic biomass to biofuels such as bioethanol and high value-added products has attracted great interest in recent decades due to the carbon neutral nature of biomass feedstock. However, there are still many key technical difficulties for the industrial application of biomass bioconversion processes. One of the challenges associated with the microorganism Saccharomyces cerevisiae that is usually used for bioethanol production refers to the inhibition of the yeast by various stress factors. These inhibitive effects seriously restrict the growth and fermentation performance of the strains, resulting in reduced bioethanol production efficiency. Therefore, improving the stress response ability of the strains is of great significance for industrial production of bioethanol. In this article, the response mechanisms of S. cerevisiae to various hydrolysate-derived stress factors including organic acids, furan aldehydes, and phenolic compounds have been reviewed. Organic acids mainly stimulate cells to induce intracellular acidification, furan aldehydes mainly break the intracellular redox balance, and phenolic compounds have a greater effect on membrane homeostasis. These damages lead to inadequate intracellular energy supply and dysregulation of transcription and translation processes, and then activate a series of stress responses. The regulation mechanisms of S. cerevisiae in response to these stress factors are discussed with regard to the cell wall/membrane, energy, amino acids, transcriptional and translational, and redox regulation. The reported key target genes and transcription factors that contribute to the improvement of the strain performance are summarized. Furthermore, the genetic engineering strategies of constructing multilevel defense and eliminating stress effects are discussed in order to provide technical strategies for robust strain construction. It is recommended that robust S. cerevisiae can be constructed with the intervention of metabolic regulation based on the specific stress responses. Rational design with multilevel gene control and intensification of key enzymes can provide good strategies for construction of robust strains. Graphical Abstract

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“…[ 44–49 ] Using the above mentioned technologies, nanocelluloses were prepared from numerous cellulosic sources, including soft and hard woods, corn, sugar beet pulp, miscanthus, banana, sisal, opuntia, ficus‐indica (cactus), flax, potato, bagasse, wheat straw, bamboo, Luffa cylindrica, grape pomace, as well as some seaweed. [ 50–52 ] The morphological characteristics of the produced cellulose derived adsorbents mainly depend on the morphological characteristics of the original fibers. In general, cellulose derived adsorbents obtained from primary cell wall fibers are much longer than those obtained from secondary cell wall fibers.…”

Section: Diverse Forms Of Cellulose‐derived Adsorbentsmentioning

confidence: 99%

Chemistry and Nanotechnology‐Oriented Strategies toward Nanocellulose for Human Water Treatment

Zha

Shi

et al. 2022

Advanced Sustainable Systems

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Conversion of lignocellulose to biofuels and chemicals via sugar platform: An updated review on chemistry and mechanisms of acid hydrolysis of lignocellulose

Cited by 201 publications

References 263 publications

Self-generated peroxyacetic acid in phosphoric acid plus hydrogen peroxide pretreatment mediated lignocellulose deconstruction and delignification

Self-generated peroxyacetic acid in phosphoric acid plus hydrogen peroxide pretreatment mediated lignocellulose deconstruction and delignification

Response mechanisms of Saccharomyces cerevisiae to the stress factors present in lignocellulose hydrolysate and strategies for constructing robust strains

Chemistry and Nanotechnology‐Oriented Strategies toward Nanocellulose for Human Water Treatment

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