Conversion of paroxysmal atrial fibrillation to sinus rhythm by intravenous pirmenol. A placebo controlled study.

Toivonen, Lauri; Nieminen, Markku S.; Manninen, Vesa; Frick, Mats

doi:10.1136/hrt.55.2.176

Cited by 12 publications

(1 citation statement)

References 21 publications

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“…38, 39 We cannot rule out the possibility that postoperative paroxysmal AF terminated spontaneously in some patients. But we evaluated the efficacy of anti-arrhythmic treatment over a 60-min period, which is relatively brief, and assumed that the placebo effects of cibenzoline and disopyramide were similar.…”

Section: Study Limitationsmentioning

confidence: 99%

Prospective Comparative Study of Intravenous Cibenzoline and Disopyramide Therapy in the Treatment of Paroxysmal Atrial Fibrillation After Cardiovascular Surgery

Kubo

Tachibana

Satoh

et al. 2010

Circ J

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Background: It has been reported that approximately one-third of patients undergoing cardiovascular surgery experience paroxysmal atrial fibrillation (AF) during the postoperative period. There is, however, little information on the selection of anti-arrhythmic drugs for terminating postoperative paroxysmal AF. Methods and Results:Between April 2007 and March 2009, 118 patients (76 men, 42 women, mean age 68±10 years) who had postoperative paroxysmal AF lasting ≥30 min were randomly assigned to receive either iv cibenzoline (70 mg, n=60) or disopyramide (50 mg, n=58) for terminating postoperative paroxysmal AF. The success rate of iv cibenzoline therapy (47%) was significantly greater than that of iv disopyramide therapy (24%; P<0.05). To identify clinical factors to increase the termination efficacy of iv cibenzoline, multivariate logistic regression was used to adjust for several covariates and to generate adjusted odds ratios (OR). The significant variables for the termination of paroxysmal AF after iv cibenzoline therapy were pretreatment with oral β-adrenergic blockers (OR =8.224, P=0.030) and smaller left atrial dimensions (OR =0.879, P=0.039). Conclusions:The efficacy of iv cibenzoline for the termination of postoperative paroxysmal AF was significantly better than that of disopyramide, especially in patients with pre-administration of oral β-adrenergic blockers and those with smaller left atrium. (Circ J 2010; 74: 1859 - 1865

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Section: Study Limitationsmentioning

confidence: 99%

Prospective Comparative Study of Intravenous Cibenzoline and Disopyramide Therapy in the Treatment of Paroxysmal Atrial Fibrillation After Cardiovascular Surgery

Kubo

Tachibana

Satoh

et al. 2010

Circ J

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Pirmenol: An antiarrhythmic drug with unique electrocardiographic features—a double‐blind placebo‐controlled comparison with quinidine

Salerno

Fifield

Farmer

et al. 1991

Clinical Cardiology

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Summary:Previous reports have stated that pirmenol is a Class IA antiarrhythmic drug that prolongs the QT interval, but did not use computerized electrocardiography. We randomized 18 patients with frequent ventricular ectopic depolarizations to pirmenol (8 patients) or quinidine (10 paticnts). Pirmenol was effective and tolerated for suppression of arrhythmia in all 7 patients treated (1 patient withdrew for personal reasons) but quinidine was effective and tolerated for 4 weeks in only 5 of 10 patients (p < 0 .OS) . Using computerized 12-lead electrocardiography. the mean change in PR interval from placebo to treatment was 5 & 18 ms for quinidine and 5 & 1 1 ms for pirmenol (p=NS). The mean change in QRS interval was 5 + 14 ms for quinidine and 10+5 ms for pirmenol (p=NS). The mean change in QT interval was 4 6 k 3 0 ms tor quinidine and 8+9 ms for pirmenol (p <0.01) and the mean change in JT interval was 41 _+36 ms for quinidine and -2+ 10 ms for pirmenol (p

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The Management of Atrial Fibrillation

Rawles

1992

Atrial Fibrillation

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Conversion of paroxysmal atrial fibrillation to sinus rhythm by intravenous pirmenol. A placebo controlled study.

Cited by 12 publications

References 21 publications

Prospective Comparative Study of Intravenous Cibenzoline and Disopyramide Therapy in the Treatment of Paroxysmal Atrial Fibrillation After Cardiovascular Surgery

Prospective Comparative Study of Intravenous Cibenzoline and Disopyramide Therapy in the Treatment of Paroxysmal Atrial Fibrillation After Cardiovascular Surgery

Pirmenol: An antiarrhythmic drug with unique electrocardiographic features—a double‐blind placebo‐controlled comparison with quinidine

The Management of Atrial Fibrillation

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