Conversion of Testosterone to Estrogens in Castrated, Adrenalectomized Human Females

West, Charles D.; Damast, Barbara; Sarro, S.D.; Pearson, Olof H.

doi:10.1016/s0021-9258(18)65904-6

Cited by 104 publications

(2 citation statements)

References 8 publications

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“…Our present results suggest that the certain levels of testosterone, such as the optimal dose observed in T-dose groups (Experiment 3), during the sexual maturation period may facilitate retention of the extinction memory. can be converted to 17b-estradiol by aromatase or 5a-DHT by 5a-reductase in its target cell [21][22][23][24]. Estrogen is known to modulate the plasticity of the memory process [25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

“…Testosterone is aromatized to a form of estrogen, 17b-estradiol [21][22][23][24], and the estrogen is known to modulate the plasticity of the memory process [25][26][27][28][29][30]. Therefore, to exclude the hypothesis that estrogen affects acquisition or retention of the extinction memory, we also examined the effects of 5a-dihydrotestosterone (5a-DHT), which is a more potent androgen that cannot be aromatized to 17b-estradiol.…”

Section: Experiments 3: Effects Of Testosterone On Acquisition and Re...mentioning

confidence: 99%

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The effect of androgen on the retention of extinction memory after conditioned taste aversion in mice

et al. 2013

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Conditioned taste aversion (CTA) induced by the application of a novel taste such as sodium saccharin (Sac) as the conditioned stimulus (CS) and a malaise-inducing agent as the unconditioned stimulus (US), results in acquisition of CTA memory to Sac. In contrast, CTA is extinguished by repeated presentations of the CS without the US, resulting in acquisition of the extinction memory. We examined the effects of androgenic hormones on acquisition and retention of extinction memory in mice. We gonadectomized sexually immature mice and continuously administered androgens to these animals. After sexual maturation, the mice underwent a conditioning period followed by an extinction period. Retrieval tests revealed that the androgen-treated group showed significantly greater retention of extinction memory than the non-treated group 5 weeks later, whereas such significant difference was not observed in acquisition of extinction memory. These results demonstrate the enhancing effect of androgens on retention of extinction memory.

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