Conversions of perimidine 2-carbamates on acetylation and their anthelmintic properties

Data on the physicochemical characteristics, theoretical calculations, reactivity and synthetic methods for perimidines are summarized. Although perimidine and some of its simple 2-substituted derivatives were obtained by Sachs back in 1909, their chemistry and key physical properties remained unknown until the early 1970s. Subsequent studies revealed many fundamental features of the perimidine system, previously not encountered in the heterocyclic series. The first comprehensive review on perimidines was published forty years ago. The period that has passed since 1980 led to the emergence of new directions and trends. Several hundred new publications have appeared, the generalization of which has become the main purpose of this article. This primarily concerns the obtaining of highly nucleophilic and stable perimidine carbenes, new methods of electrophilic substitution and oxidation, establishment of a close relationship between perimidines and proton sponges, and modern theoretical calculations. Based on perimidines, many different polycondensed systems have been obtained. Applied research has developed especially rapidly in recent years. Many new compounds based on perimidines related to chemosensors, analytical reagents, dyes, metal catalysts, electronic devices, nanotechnology, and medical chemistry have been proposed. Some information under review is presented as Supplementary Materials. It contains six tables, which include data on the basicity constants of perimidines, details of some synthetic methods for perimidines and fused analogs and also a list of biological activities of perimidines. The bibliography includes 387 references.

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Perimidines: a unique π-amphoteric heteroaromatic system

Пожарский

Gulevskaya

Claramunt

et al. 2020

Russ. Chem. Rev.

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Review on Perimidines: A synthetic Pathways Approach

Yelmame¹,

Jagtap

2021

Mat. Sci. Res. India

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Perimidines are available in an assortment of drugs and general use industrial structures and perimidines are also significant primary theme because of their extraordinary method of physiological activity. Thus the underlying significance of perimidine moiety has evoked a lot of interest in the field of natural blend and compound science to build up some better than ever amalgamation of this atomic skeleton. In this review, we have depicted a modern outline on the new advances in the different manufactured approaches of perimidine. The review covers the essential applied and down to earth synergist blend like, green methodologies, metal catalysed responses, microwave illumination, grinding and so forth which are critical for developing perimidine skeleton. This review will fulfill the assumptions for peruses who are keen on the advancement of the field and searching for an update. It will animate analysts to grow new and innovative manufactured admittance to this heterocyclic framework, which will be instrumental in the headway of perimidine science. This review provides an overview of various synthetic methodologies for the synthesis of a wide range of perimidine derivatives with applications in material chemistry, drug discovery, polymer chemistry, photo sensors, dye chemistry, and other fields.

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Synthesis and Reactions of Perimidines and Their Fused Systems

Farghaly

Al‐Hussain

Muhammad

et al. 2020

COC

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Perimidines are peri-naphtho-fused derivatives of pyrimidine. They are of particular interest as they are a rare example of an azine in which the lone pair of electrons of a pyrrole-like nitrogen participates in the π-system of the molecule. Perimidine is an interesting class of heterocyclic compounds. Various synthetic analogs of perimidines have been prepared and evaluated for many pharmacological activities in different models with desired findings. They exhibit biological activities as antitumor, antiulcer, antimicrobial and antifungal agents. This review is an attempt to organize the synthesis and chemical reactions of perimidine analogs reported till date systematically since 1955. It should be noted that this review is the first one that includes the preparation and reactions of the perimidine ring.

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Conversions of perimidine 2-carbamates on acetylation and their anthelmintic properties

Cited by 3 publications

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Perimidines: a unique π-amphoteric heteroaromatic system

Perimidines: a unique π-amphoteric heteroaromatic system

Review on Perimidines: A synthetic Pathways Approach

Synthesis and Reactions of Perimidines and Their Fused Systems

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