Converting‐enzyme Inhibition and 1‐sarcosine‐8‐isoleucine‐angiotensin Ii: Effects on Renal Function in the Dehydrated Sheep

Yesberg, Nancy E.; Henderson, Myrna; Dallemagne, Catherine; Law, Sandra; Hamilton, Dan; Cross, R. B.

doi:10.1113/expphysiol.1984.sp002774

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…In previous experiments where the effect of an ACE inhibitor on renal function was investigated in sheep, samples were taken either during the continuous i.v. infusion of inhibitor 13 , or very shortly (less than 200 minutes) after the bolus dosage of inhibitor 19,20 . However, Fitzpatrick et al 6 compared the effects of intermittent (twice daily) and continuous Captopril administration on some aspects of renal function.…”

Section: Discussionmentioning

confidence: 99%

“…Several experiments in the past have addressed the effects of angiotensinconverting enzyme (ACE) inhibition on renal function in sheep under various conditions such as in the dehydrated animal, in sodium-restricted sheep and in sheep treated with adrenocorticotropic hormone 13,19,20 . Failure of angiotensin II inhibition to result in an increase in urinary sodium excretion in sheep on a low sodium diet led to speculation that sheep may be less dependent on angiotensin II in regulating sodium excretion than are other species 13 .…”

Section: Introductionmentioning

confidence: 99%

“…Failure of angiotensin II inhibition to result in an increase in urinary sodium excretion in sheep on a low sodium diet led to speculation that sheep may be less dependent on angiotensin II in regulating sodium excretion than are other species 13 . However, infusion of dehydrated sheep with the ACE inhibitor, D-3 -mercapto-2 methylpropanoyl-L-proline (Captopril, Bristol-Myers Squibb), did produce a rise in urinary sodium excretion over the 60-80-minute monitoring period following infusion 20 .…”

Section: Introductionmentioning

confidence: 99%

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The effect of an angiotensin-converting enzyme inhibitor on water and electrolyte balance in water-restricted sheep

Meintjes¹,

Engelbrecht²

1999

J. S. Afr. Vet. Assoc.

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The importance of angiotensin II in the regulation of water and electrolyte balance in sheep is questionable. In this trial the effects of an angiotensin-converting enzyme (ACE) inhibitor were quantified in sheep on restricted water intake. Comparing the phase of water restriction only with that of water restriction plus ACE inhibition, significant increases were observed during the latter phase in urine volume, sodium and potassium excretion via the urine, sodium concentration in the plasma and osmolar clearance. Urine osmolarity decreased with inhibition of angiotensin II formation while variables such as water, sodium and potassium loss via the faeces were unaffected. Most of the renal effects of ACE inhibition, except the increase in urinary potassium excretion, were explicable in terms of the established functions of angiotensin II. Furthermore, results of this trial indicate that angiotensin II has no significant effect on the intestine in regulating water and electrolyte excretion via the faeces

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of an angiotensin-converting enzyme inhibitor on water and electrolyte balance in water-restricted sheep

Meintjes¹,

Engelbrecht²

1999

J. S. Afr. Vet. Assoc.

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“…Sheep were prepared for renal function tests as described by Yesberg, Henderson, Dallemagne, Law, Hamilton & Cross (1984). Both jugular veins were catheterized after local anaesthesia with 2.0 ml lignocaine (Xylocaine 2 %, Astra; s.c.).…”

Section: Methodsmentioning

confidence: 99%

Comparison of a single‐injection technique and inulin clearance for determining glomerular filtration rate in the sheep

Wholohan

Yesberg²,

Cross³

1991

Experimental Physiology

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SUMMARYGlomerular filtration rate (GFR) was assessed over a 2 h period by the clearance of inulin (Cin) and in the subsequent 2 h period by a single-injection technique using radiolabelled sodium iothalamate (Ci.0) or chromium-EDTA (CEDTA). Regression analysis yielded a significant correlation (P < 0.05) between the standard clearance technique and the single-injection method, with the relationship Ciot = -10-67 + 1.25Cin with a significant correlation coefficient of r = 0-71 (P < 0.02).

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“…Plasma renin activity (PRA) also increased during water deprivation in camels (Al-Qarawi et al, 1997;, sheep , and goats . In addition, plasma angiotensin n increased during dehydration in camels (Al-Qarawi et al, 1997), sheep (Yesberg et al, 1984), and cattle . Plasma Cortisol concentrations did not change in camels during 8-10 days of dehydration .…”

Section: Introductionmentioning

confidence: 99%

Regulation of water and electrolyte metabolism during dehydration and rehydration in camels

Al‐Qarawi

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The mineralocorticoid hormones especially aldosterone have an important role in regulating body electrolyte balance by increasing Na" reabsorption and K" excretion; thereby, assisting in the regulation of the body fluid volume. The present study was undertaken to determine which pathway is responsible for the secretion of aldosterone in the dehydrated camel; either the renin-angiotensin axis or the ACTH axis. Adrenocorticotropic hormone (ACTH) and enalapril, an angiotensin-converting enzyme inhibitor (ACE-I), were utilized in two separate experiments in dehydrated and control (hydration) arabian camels rCamelus dromedariusl Forty 3-5 year one-humped camels rCamelus dromedarius). (20 males; 20 females) were used. In the first experiment the camels were randomly assigned to four groups of 5 camels each: 1) hydration (firee access to water), 2) hydration plus enalapril, 3) dehydration (10 days of water deprivation), and 4) dehydration (10 days of water deprivation) plus enalapril. Enalapril (0.2 |xg/kg) induced a sharp decrease in plasma Na"^ and an increase in plasma K" concentrations in the dehydrated camels but not in the hydrated camels. After enaiapril administration, plasma osmolality decreased significantly in both dehydrated and hydrated camels. Enaiapril administration induced a decrease in plasma aldosterone concentrations in both the dehydrated and hydrated camels. Plasma angiotensin 11 concentrations decreased in the dehydrated camels but not the hydrated camels after enaiapril administration. Plasma renin activity (PRA) increased significantly in the dehydrated camels after enaiapril administration but not in hydrated animals. In the second experiment, ACTH administration (0.4 lU / kg) had no significant efifects on plasma electrolytes and osmolality in either the dehydrated or hydrated camels. The administration of ACTH induced a sharp increase in plasma Cortisol concentrations in both the dehydrated and hydrated camels. Plasma aldosterone concentrations, however, increased only in the dehydrated camels and declined in 24 hours in the presence of continuous administration of ACTH. The present study clearly shows that both angiotensin 11 and ACTH stimulate aldosterone secretion during dehydration in camels. However, due to the parallel increase in PRA, plasma angiotensin 11 and plasma aldosterone in dehydrated camels without any parallel changes in plasma Cortisol or ACTH, the effect of angiotensin II seems to be dominant over ACTH.

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Converting‐enzyme Inhibition and 1‐sarcosine‐8‐isoleucine‐angiotensin Ii: Effects on Renal Function in the Dehydrated Sheep

Cited by 4 publications

References 6 publications

The effect of an angiotensin-converting enzyme inhibitor on water and electrolyte balance in water-restricted sheep

The effect of an angiotensin-converting enzyme inhibitor on water and electrolyte balance in water-restricted sheep

Comparison of a single‐injection technique and inulin clearance for determining glomerular filtration rate in the sheep

Regulation of water and electrolyte metabolism during dehydration and rehydration in camels

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