Spatio-temporal data are ubiquitous in the agricultural, ecological, and environmental sciences, and their study is important for understanding and predicting a wide variety of processes. One of the difficulties with modeling spatial processes that change in time is the complexity of the dependence structures that must describe how such a process varies, and the presence of high-dimensional complex datasets and large prediction domains. It is particularly challenging to specify parameterizations for nonlinear dynamic spatio-temporal models (DSTMs) that are simultaneously useful scientifically and efficient computationally. Statisticians have developed deep hierarchical models that can accommodate process complexity as well as the uncertainties in the predictions and inference. However, these models can be expensive and are typically application specific. On the other hand, the machine learning community has developed alternative "deep learning" approaches for nonlinear spatio-temporal modeling. These models are flexible yet are typically not implemented in a probabilistic framework. The two paradigms have many things in common and suggest hybrid approaches that can benefit from elements of each framework. This overview paper presents a brief introduction to the deep hierarchical DSTM (DH-DSTM) framework, and deep models in machine learning, culminating with the deep neural DSTM (DN-DSTM). Recent approaches that combine elements from DH-DSTMs and echo state network DN-DSTMs are presented as illustrations.