Convulsions néonatales révélant une hypomagnésémie congénitale familiale

Dehanin, T.; Sow, Adjaratou Dieynabou; Sène, Matar; Basse, Anna Modji; Fall, Amadou Lamine; Seck, Lala Bouna; Touré, Kamadore; Diop, Aissatou; Sow, H. D.; Ndiaye, M.

doi:10.1016/j.arcped.2013.08.019

Cited by 7 publications

(2 citation statements)

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“…It is important for enzyme activation, muscular contraction and relaxation, neuronal activity and neurotransmitter release, and cardiovascular activities (such as cardiac function, vasomotor tone) ( 1 , 2 ). Hypomagnesemia in neonates often manifests as neonatal seizures and psychomotor delay ( 3 , 4 ). It may be a congenital condition and researchers have reported that it is associated with therapeutic hypothermia in neonates ( 3 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated With Changes in Magnesium Levels in Asymptomatic Neonates: A Longitudinal Analysis

Mehta¹,

Shitole²,

Setia³

2016

Iran J Pediatr

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Background:Neonates and infants with hypomagnesemia present with seizures and psychomotor delay.Objectives:The present study evaluated the changes in magnesium (Mg) levels and factors associated with these in the first three days of life.Materials and Methods:We monitored 50 clinically asymptomatic neonates; they were not given any magnesium supplements even if they had hypomagnesemia at baseline. The variables analysed were: serum Mg; gestational age; birth weight; length; and the ponderal index. We used random effects (RE) models for longitudinal analysis of these data.Results:The mean standard deviation (SD) gestational age was 36.3 (3.6) weeks and the mean (SD) weight was 2604.2 (754.4) grams. About 31% of the neonates had hypomagnesemia (< 1.6 mg/dL) on day one; however, all had normal magnesium levels by day three of life (P < 0.001). At birth, after adjusting for intrauterine growth retardation status (IUGR), serum Mg levels were lower by 0.0097 mg/dL (95% CI: -0.019 to -0.0003) per 100 grams increase in weight of the neonate. After adjusting for IUGR status, the mean increase in the serum Mg levels was 0.14 mg/dL (95% confidence intervals [CI]: 0.10 to 0.18) per day. The per-day increase in magnesium levels was significantly higher in low birth weight babies (0.10, 95% CI: 0.01 to 0.18) compared with normal birth weight babies.Conclusions:Asymptomatic neonates may have a high prevalence of hypomagnesemia; however, the levels become normal without any magnesium supplementation. Even though regular monitoring of magnesium levels is useful, no supplements are required - particularly in clinically asymptomatic neonates.

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Section: Introductionmentioning

confidence: 99%

“…Hypomagnesemia in neonates often manifests as neonatal seizures and psychomotor delay ( 3 , 4 ). It may be a congenital condition and researchers have reported that it is associated with therapeutic hypothermia in neonates ( 3 , 5 ). It is often seen in children born to women with gestational diabetes ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%