Cooked Rice Inhibits Hepatic Fat Accumulation by Regulating Lipid Metabolism–Related Gene Expression in Mice Fed a High-Fat Diet

Choi, Won Hee; Um, Min Young; Ahn, Jiyun; Jung, Chang Hwa; Ha, Tae Youl

doi:10.1089/jmf.2013.3058

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…In particular, excessive fat accumulation in the liver caused by obesity in general dysregulates insulin action in the liver, leading to insulin resistance [6]. Recent prospective diet intervention studies indicate that 5%–10% weight loss improves liver histology and reduces hepatic triglycerides [7,8].…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract of Taheebo Attenuates Increase in Body Weight and Fatty Liver in Mice Fed a High-Fat Diet

Choi

Ahn

et al. 2014

Molecules

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Abstract:We evaluated whether intake of an ethanolic extract of Taheebo (TBE) from Tabebuia avellanedae protects against body weight increase and fat accumulation in mice with high-fat diet (HFD)-induced obesity. Four-week old male C57BL/6 mice were fed a HFD (25% fat, w/w) for 11 weeks. The diet of control (HFD) mice was supplemented with vehicle (0.5% sodium carboxymethyl cellulose by gavage); the diet of experimental (TBE) mice was supplemented with TBE (150 mg/kg body weight/day by gavage). Mice administered TBE had significantly reduced body weight gain, fat accumulation in the liver, and fat pad weight, compared to HFD mice. Reduced hypertrophy of fat cells was also observed in TBE mice. Mice administered TBE also showed significantly lower serum levels of triglycerides, insulin, and leptin. Lipid profiles and levels of mRNAs and proteins related to lipid metabolism were determined in liver and white adipose tissue of the mice. Expression of mRNA and proteins related to lipogenesis were decreased in TBE-administered mice compared to mice fed HFD alone. These results suggest that TBE inhibits obesity and fat accumulation by regulation of gene expression related to lipid metabolism in HFD-induced obesity in mice.

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Section: Introductionmentioning

confidence: 99%

Ethanolic Extract of Taheebo Attenuates Increase in Body Weight and Fatty Liver in Mice Fed a High-Fat Diet

Choi

Ahn

et al. 2014

Molecules

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“…For the six selected herbs, either themselves or the ingredients were reported to be effective in obesity, IR, dyslipidemia, or NAFLD. Coix lacryma-jobi has effects on obesity and hyperlipidemia through modulating TNF-alpha and leptin [ 18 ], and Oryza sativa decreases hepatic fat accumulation, hyperlipidemia [ 19 ], and hepatic steatosis [ 20 ]. Liriope platyphylla improves fat accumulation and glucose regulation [ 21 ] and stimulates insulin secretion and suppresses fatty liver formation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Seyoeum on Obesity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease of High‐Fat Diet‐Fed C57BL/6 Mice

Seol

Kim

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background This study was performed to evaluate the effect of Seyoeum (SYE), a novel herbal meal replacement, on insulin resistance and nonalcoholic fatty liver disease (NAFLD) in obese mice fed with a high-fat diet (HFD). Methods SYE contained six kinds of herbal powder such as Coix lacryma-jobi, Oryza sativa, Sesamum indicum, Glycine max, Liriope platyphylla, and Dioscorea batatas. Male C57BL/6 mice were divided into four groups: normal chow (NC), HFD, SYE, and HFD plus SYE (HFD + SYE). The mice in groups other than NC were fed HFD for 9 weeks to induce obesity and then were fed each diet for 6 weeks. Clinical markers related to obesity, diabetes, and NAFLD were examined and gene expressions related to inflammation and insulin receptor were determined. Results Compared with HFD group, body weight, serum glucose, serum insulin, HOMA-IR, total cholesterol, triglyceride, epididymal fat pad weight, liver weight, and inflammatory gene expression were significantly reduced in SYE group. Insulin receptor gene expression increased in SYE group. Conclusions Based on these results, we conclude that SYE improved obesity and insulin resistance in high-fat fed obese mice. Our findings suggest that SYE could be a beneficial meal replacement through these antiobesity and anti-insulin resistance effects.

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“…It increased mRNA levels of anti-oxidant catalase, superoxide dismutase 1, and glutathione peroxidase 1 in obese mice (24). In liver, even mild CR decreased inflammatory gene expression such as MCP-1 and lipogenic gene expressions including SREBPs and PPARγ (25). Anti-inflammatory effects of CR have also been shown in non-metabolic tissues.…”

Section: Anti-senoinflammation Of Calorie Restriction (Cr)mentioning

confidence: 99%

Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis

et al. 2019

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Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity.

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Cooked Rice Inhibits Hepatic Fat Accumulation by Regulating Lipid Metabolism–Related Gene Expression in Mice Fed a High-Fat Diet

Cited by 7 publications

References 34 publications

Ethanolic Extract of Taheebo Attenuates Increase in Body Weight and Fatty Liver in Mice Fed a High-Fat Diet

Ethanolic Extract of Taheebo Attenuates Increase in Body Weight and Fatty Liver in Mice Fed a High-Fat Diet

Effect of Seyoeum on Obesity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease of High‐Fat Diet‐Fed C57BL/6 Mice

Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis

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