Cooled radiofrequency ablation of genicular nerves for knee osteoarthritis

Abstract

Knee osteoarthritis (OA) is a prevalent and debilitating musculoskeletal condition that significantly affects the quality of life of millions of individuals worldwide. In recent years, cooled radiofrequency ablation (CRFA) has become a viable treatment option for knee OA. This review thoroughly evaluated the existing literature on CRFA therapy for knee OA. It delved into the mechanisms behind CRFA, evaluated its clinical efficacy, and investigated potential avenues for future research and application. The insights gained from this review are crucial for healthcare professionals, researchers, and policymakers, offering an updated perspective on CRFA's role as a viable therapeutic option for knee OA.

Effectiveness of the Cooled Radiofrequency Ablation of Genicular Nerves in Patients with Chronic Knee Pain Due to Osteoarthritis: A Double-Blind, Randomized, Controlled Study

“…Since the first case report on the effectiveness of cooled RFA in patients with chronic knee pain [ 14 ], prospective and retrospective studies have been conducted to confirm the efficacy of the cooled RFA of genicular nerves in patients with chronic knee pain due to OA [ 8 ]. These studies have demonstrated that the cooled RFA of genicular nerves provides notable pain relief, improved functional outcomes, and positive patient-reported experiences in patients with chronic knee pain [ 8 ]. Moreover, recent prospective studies observed sustained significant pain relief for up to two years in approximately half of the patients who underwent this procedure [ 15 , 16 ].…”

“…The cooling mechanism is designed to minimize damage to adjacent structures and increase the size of lesions, which may enhance the safety and efficacy of the RFA treatment; these features have led to the growing application of cooled RFA on genicular neurotomy [ 6 , 7 ]. Furthermore, there is increasing evidence that supports the clinical efficacy of cooled RFA targeting genicular nerves for knee OA [ 8 ]. Nevertheless, no study has been conducted to eliminate the potential influence of a placebo effect associated with this procedure.…”

I Am Afraid I Will Not Be Able to Walk, That Is What Worries Me—The Experience of Patients with Knee Osteoarthritis before Total Knee Arthroplasty: A Qualitative Study

“…In recent years, radiofrequency ablation (CRFA) has emerged as a promising alternative treatment modality for KOA. In contrast to conventional radiofrequency procedures, CRFA employs advanced cooling technology to target and modulate sensory nerves responsible for pain signal transmission [8].…”