Chondrules are iconic sub-millimeter spheroids representing the most abundant high-temperature dust formed during the evolution of the circumsolar disk. Chondrules have been the subject of a great deal of research, but no consensus has yet emerged as to their formation conditions. In particular, the question of whether chondrules are of nebular or planetary origin remains largely debated. Building upon decades of chondrule investigation and recent headways in combining petrographic observations and O−Ti−Cr isotopic compositions, we here propose a comprehensive vision of chondrule formation. This holistic approach points toward a nebular origin of both NC and CC chondrules, with repetitive high-temperature recycling processes controlling the petrographic and isotopic diversities shown by chondrules. Chondrule precursors correspond to mixing between (i) early-formed refractory inclusions ± NC-like dust and (ii) previous generation of chondrules ± CI-like material. Chondrule formation took place under open conditions with gas-melt interactions with multi-species gas (H2O, Mg, SiO) playing a key role for establishing their characteristics. Petrographic and isotopic systematics do not support disk-wide transport of chondrules but point toward local formation of chondrules within their respective accretion reservoirs. Altogether, this shows that several generations of genetically-related chondrules (i.e., deriving from each other) co-exist in chondrites. In addition to supporting the nebular brand of chondrule-forming scenarios, this argues for repetitive and extremely localized heating events for producing chondrules.