Cooperative control of oxidative metabolism by PGC‐1α and PPARβ: implications for exercise‐induced mitochondrial remodelling in skeletal muscle

Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults

“…Although there is no clear explanation for the overall lack of change in biogenesis markers despite the substantial increase in mitochondrial content found in this study, the contradictory results might be related to the timing of biopsy. Furthermore, researchers have recently reevaluated the role of PGC-1α on mitochondrial biogenesis and showed that other proteins, such as PPARβ, may also be important in regulating mitochondrial biogenesis (Islam & Bonafiglia, 2019;Islam, Hood, & Gurd, 2020). Future studies should investigate how RT may be affecting other regulators of mitochondrial biogenesis in both younger and older individuals.…”

Human Skeletal Muscle Mitochondrial Adaptations Following Resistance Exercise Training

“…There is ample evidence to suggest that the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) protein is largely involved with mitochondrial biogenesis [42]. For instance, PGC-1α works in concert with other proteins, such as peroxisome proliferator-activated receptor beta (PPARβ), to facilitate interactions with other nuclear transcription factors to up-or down-regulate mitochondrial biogenesis [8,43]. PGC-1α has been shown to regulate the transcriptional activity of the peroxisome proliferator-activated receptor gamma (PPARγ) nuclear receptor that in turn up-regulates the expression of electron transport chain genes [44].…”