2016
DOI: 10.1371/journal.pone.0157801
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Cooperative Effect of miR-141-3p and miR-145-5p in the Regulation of Targets in Clear Cell Renal Cell Carcinoma

Abstract: BackgroundDue to the poor prognosis for advanced renal cell carcinoma (RCC), there is an urgent need for new therapeutic targets and for prognostic markers to identify high risk tumors. MicroRNAs (miRNAs) are frequently dysregulated in tumors, play a crucial role during carcinogenesis and therefore might be promising new biomarkers. In previous studies, we identified miR-141-3p and miR-145-5p to be downregulated in clear cell RCC (ccRCC). Our objective was to investigate the functional association of these miR… Show more

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Cited by 67 publications
(47 citation statements)
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“…As mentioned above, these two microRNAs also act as regulators of numerous target genes that have been already validated so far in urinary bladder and other solid cancers (target characteristics are given in Table ). Moreover, based on our data of prognostic relevance of miR‐199a‐3p and miR‐214‐3p, the view is supported that such a regulatory network or at least a cooperative action of the microRNAs as shown in other cancer examples could also exist in bladder cancer. A detailed investigation of the functional role of the two miRNAs would be worthwhile but was beyond the scope of this study.…”
Section: Discussionsupporting
confidence: 62%
“…As mentioned above, these two microRNAs also act as regulators of numerous target genes that have been already validated so far in urinary bladder and other solid cancers (target characteristics are given in Table ). Moreover, based on our data of prognostic relevance of miR‐199a‐3p and miR‐214‐3p, the view is supported that such a regulatory network or at least a cooperative action of the microRNAs as shown in other cancer examples could also exist in bladder cancer. A detailed investigation of the functional role of the two miRNAs would be worthwhile but was beyond the scope of this study.…”
Section: Discussionsupporting
confidence: 62%
“…Numerous micro-RNAs have also been shown to be involved in the regulation of LOX expression. In clear cell renal cell carcinoma, both miR-141-3p and miR-145-5p directly bind to the 3â€Č untranslated region of the LOX mRNA and cooperatively downregulate LOX expression, thereby suppressing the progression of clear cell renal cell carcinoma [ 72 ]. In granulosa lutein cells, miR-29a directly downregulates LOX expression; as a result, TGF-ÎČ1 upregulates LOX expression by downregulating miR-29a [ 73 ].…”
Section: Lox Regulationmentioning
confidence: 99%
“…MicroRNAs (miRNAs), 22-25 nt in length, are a group of small non-coding RNAs which are crucial in various biological processes including cell growth, cell apoptosis, cell cycle control, cell differentiation and cell migration/invasion. miR-141-3p has been found to be extensively involved in diverse malignant tumors such as gastric cancer, hepatocellular carcinoma, prostate cancer, renal cell and esophageal carcinoma (10)(11)(12)(13)(14). Qiu et al reported that miR-141-3p inhibited human stromal stem cell proliferation by targeting cell division cycle 25A (CDC25A) (15).…”
Section: Introductionmentioning
confidence: 99%