Coordinate Hormonal and Synaptic Regulation of Vasopressin Messenger RNA

Baldino, Frank; O'Kane, Teresa M.; Fitzpatrick-McElligott, S; Wolfson, B.

doi:10.1126/science.3406747

Cited by 63 publications

(14 citation statements)

References 18 publications

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“…For example, there is electrophysiological evidence for direct connections between the lateral septum and amygdala and the ipsilateral paraventricular and supraoptic nuclei, which are inhibitory to AVP neurons in these nuclei (Poulain et al 1981;Cirino and Renaud 1985;Baldino et al 1988). In rats, the lateral septum (as well as ventral septum, lateral habenular nucleus, and midbrain structures) receives input from sexually dimorphic vasopressinergic cells in the bed nucleus of the stria terminalis (BNST) and medial amygdala (De Vries et al 1994a;1994b).…”

Section: Discussionmentioning

confidence: 99%

Pituitary-Adrenal Cortical Responses to Low-Dose Physostigmine and Arginine Vasopressin Administration in Normal Women and Men

Rubín

Sekula

O’Toole

et al. 1999

Neuropsychopharmacology

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Animal studies indicate that central cholinergic neurotransmission stimulates CRH secretion, but several human studies suggest that the hypothalamo-pituitaryadrenal cortical (HPA) axis may be activated only by doses of cholinergic agonists that produce noxious side effects and, by inference, a nonspecific stress response. Physostigmine (PHYSO), a reversible cholinesterase inhibitor, was administered to normal women and men at a dose that elevated plasma ACTH cortisol, and arginine vasopressin (AVP) concentrations but produced few or no side effects. Exogenous AVP also was administered alone and following PHYSO, to determine if it would augment the effect of PHYSO on the HPA axis. Fourteen normal women and 14 normal men matched to the women on age and race underwent four test sessions 5 to 7 days apart: PHYSO (8 g/kg IV), AVP (0.08 U/kg IM), PHYSO plus AVP, and saline control. Serial blood samples taken before and after pharmacologic challenge were analyzed for ACTH , cortisol, and AVP. PHYSO and AVP administration produced no side effects in about half the subjects and mild side effects in the other half, with no significant female-male differences overall. There also were no significant female-male differences in ACTH or cortisol responses to AVP. In contrast, the men had significantly greater ACTH There is ample evidence from animal studies that cholinergic neurotransmission stimulates both CRH and arginine vasopressin (AVP) secretion (Gregg 1985;Tuomisto and Männistö 1985;Assenmacher et al. 1987 Received March 20, 1998; revised July 1, 1998; accepted July 10, 1998. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 20 , NO . 5 Pituitary-Adrenal Responses to Physostigmine and AVP 435 and Grossman 1990;Michels et al. 1991;Okuda et al. 1993;Whitnall 1993;Coiro et al. 1995;Calogero 1995;Ohmori et al. 1995), both of which stimulate ACTH secretion (Rivier et al. 1990;Antoni 1993). Several studies in humans, however, suggest that the hypothalamo-pituitary-adrenal cortical (HPA) axis is activated only by doses of cholinergic agonists that produce noxious side effects, especially nausea (Carroll et al. 1980;Davis et al. 1982;Doerr and Berger 1983;Nurnberger et al. 1983;Lewis et al. 1984;Krieg et al. 1987;Freeman et al. 1990), and, by inference, a nonspecific stress response, nausea being a powerful stimulus to AVP release (Nussey et al. 1988;Koch et al. 1990;Kohl 1992). In the present study, a dose of physostigmine (PHYSO), a reversible cholinesterase inhibitor, was established that discernibly elevated plasma ACTH and cortisol concentrations in normal subjects but produced few or no side effects. The purpose was to develop a pharmacologic cholinergic challenge to the central nervous system as specific as possible, with which to test the cholinergic overactivity hypothesis of major depression (Dilsaver 1986;Janowsky and Overstreet 1995), as reflected by HPA axis hormone responses in patients compared to controls.Under the hypothesis that a low, minimal side-effect producing dose of PHYSO would enhance the secretion...

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Section: Discussionmentioning

confidence: 99%

Pituitary-Adrenal Cortical Responses to Low-Dose Physostigmine and Arginine Vasopressin Administration in Normal Women and Men

Rubín

Sekula

O’Toole

et al. 1999

Neuropsychopharmacology

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show abstract

“…While it was originally thought that AVP and OT were produced in mutually exclusive sets of neurons(Mohr and others, 1988), it has become clear that at least some magnocellular neurons can produce both AVP and OT(Baldino, Jr. and others, 1988; Kiyama and Emson, 1990; Mezey and Kiss, 1991; Xi and others, 1999; Gainer, 2012). However, no instances of colocalization have been reported in parvocellular neurons.…”

Section: Neurochemical Signaling In the Sbnnmentioning

confidence: 99%

“…The limited existing data suggests that there may be large differences in the ratios of AVP/OT produced. There is also evidence that there may be dynamic changes in the relative amounts of OT and AVP produced in response to factors such as synaptic activity and hormones(Baldino and others, 1988; Telleria-Diaz and others, 2001). In summary, although it is clear that AVP/OT can be colocalized, is not known how frequently this may occur or if the release of different ratios of AVP/OT might have functional consequences in the control of social behavior.…”

Section: Neurochemical Signaling In the Sbnnmentioning

confidence: 99%

Species, sex and individual differences in the vasotocin/vasopressin system: Relationship to neurochemical signaling in the social behavior neural network

Albers

2015

Frontiers in Neuroendocrinology

169

152

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Arginine-vasotocin(AVT)/arginine vasopressin (AVP) are members of the AVP/oxytocin (OT) superfamily of peptides that are involved in the regulation of social behavior, social cognition and emotion. Comparative studies have revealed that AVT/AVP and their receptors are found throughout the “Social Behavior Neural Network” and display the properties expected from a signaling system that controls social behavior (i.e., species, sex and individual differences and modulation by gonadal hormones and social factors). Neurochemical signaling within the SBNN likely involves a complex combination of synaptic mechanisms that co-release multiple chemical signals (e.g., classical neurotransmitters and AVT/AVP as well as other peptides) and non-synaptic mechanisms (i.e., volume transmission). Crosstalk between AVP/OT peptides and receptors within the SBNN is likely. A better understanding of the functional properties of neurochemical signaling in the SBNN will allow for a more refined examination of the relationships between this peptide system and species, sex and individual differences in sociality.

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“…Furthermore, septal lesions alter food and water intake, which is also observed after hypothalamic lesions (Harvey and Hunt, 1965; Lorens and Kondo, 1969; Stoller, 1972). Electrically stimulating septal nuclei results in lowered arousal, hypoactivity, reduced rates of response, and even sleep and induces autonomic responses such as decreased blood pressure, cardiac deceleration, and inhibition of pituitary–adrenal activity as well as somatomotor effects in rats and cats (Malmo, 1961, 1965; Covian et al, 1964; Holdstock, 1967; Baldino et al, 1988). Furthermore, abnormalities in the septal region have been associated with schizophrenia and depression (Zeman and King, 1958; Averback, 1981; Brisch et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Reward Contingency Modulates Neuronal Activity in Rat Septal Nuclei during Elemental and Configural Association Tasks

Matsuyama¹,

Uwano²,

Hori³

et al. 2011

Front. Behav. Neurosci.

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It has been suggested that septal nuclei are important in the control of behavior during various reward and non-reward situations. In the present study, neuronal activity was recorded from rat septal nuclei during discrimination of conditioned sensory stimuli (CSs) of the medial forebrain bundle associated with or without a reward (sucrose solution or intracranial self-stimulation, ICSS). Rats were trained to lick a spout protruding close to the mouth just after a CS to obtain a reward stimulus. The CSs included both elemental and configural stimuli. In the configural condition, the reward contingency of the stimuli presented together was opposite to that of each elemental stimulus presented alone, although the same sensory stimuli were involved. Of the 72 responsive septal neurons, 18 responded selectively to the CSs predicting reward (CS+-related), four to the CSs predicting non-reward (CS0-related), nine to some CSs predicting reward or non-reward, and 15 non-differentially to all CSs. The remaining 26 neurons responded mainly during the ingestion/ICSS phase. A multivariate analysis of the septal neuronal responses to elemental and configural stimuli indicated that septal neurons encoded the CSs based on reward contingency, regardless of the stimulus physical properties and were categorized into three groups; CSs predicting the sucrose solution, CSs predicting a non-reward, and CSs predicting ICSS. The results suggest that septal nuclei are deeply involved in discriminating the reward contingency of environmental stimuli to manifest appropriate behaviors in response to changing stimuli.

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Coordinate Hormonal and Synaptic Regulation of Vasopressin Messenger RNA

Cited by 63 publications

References 18 publications

Pituitary-Adrenal Cortical Responses to Low-Dose Physostigmine and Arginine Vasopressin Administration in Normal Women and Men

Pituitary-Adrenal Cortical Responses to Low-Dose Physostigmine and Arginine Vasopressin Administration in Normal Women and Men

Species, sex and individual differences in the vasotocin/vasopressin system: Relationship to neurochemical signaling in the social behavior neural network

Reward Contingency Modulates Neuronal Activity in Rat Septal Nuclei during Elemental and Configural Association Tasks

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